Abstract：Objective To analyze the clinical characteristics of young lung cancer patients, and to explore the risk factors for onset oflung cancer in the young. Methods A 1∶3 matched case-control study was conducted. 74 young lung cancer patients hospitalized in Department of Respiratory Medicine, the 988 Hospital of PLA from January 2011 to June 2019 were selected, and then analyzed their clinical features. 222 healthy persons undergoing physical examination in the same hospital were simultaneously selected to participate in the questionnaire survey. Single-factor analysis and multi-factor logistic regression analysis were performed to identify risk factors related to young lung cancer through intergroup comparison. Results Among the 74 young lung cancer patients, 23 (31.08%) had no obvious symptoms of discomfort in the early days, and the other 51 showed non-specific symptoms such as cough, expectoration, hemoptysis, chest pain, shortness of breath, hoarseness and weight loss. At the time of diagnosis, 60.81% of the subjects hadvariousdegrees and different parts of metastasis. According to the analysis of pathological types, adenocarcinoma accounted for the largest proportion (64.86%), followed by squamous cell carcinoma (16.22%) and advanced lung cancer (40.54%). Logistic regression analysis revealed that body mass index (OR=0.637, P=0.012), fresh fruit consumption per week (OR=0.720, P=0.001), and regular garlic consumption (OR=0.208, P=0.008) were protective factors for lung cancer in young people, while family history of cancer (OR=5.064, P<0.001), frequent smoking (OR=4.121, P<0.001), passive smoking (OR=15.658, P<0.001), long-term lack of sleep (OR=2.423, P=0.025), long-term exposure to dust or cotton dust (OR=4.001, P<0.001), living in a house newly built or newly decorated within six months (OR=1.879, P<0.001) and long-term mental depression (OR=3.099, P=0.011) were independent risk factors for lung cancer in young people (all P<0.05). Conclusions Young lung cancer patients had poor clinical specificity and high degree of malignancy. The cause of the disease may be the comprehensive result of multiple factors; and hence, integrated intervention measures targeted on special population exposed to risk factors should be taken to prevent the onset of lung cancer.
李海燕, 王保健. 青年肺癌患者临床特征及发病相关因素分析[J]. 实用预防医学, 2020, 27(6): 699-703.
LI Hai-yan, WANG Bao-jian. Clinical characteristics of young lung cancer patientsand factors relevant to its onset. , 2020, 27(6): 699-703.
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2020, Vol. 27 
