Abstract：Objective To investigate the infection status and genotyping of human metapneumovirus (HMPV) in hospitalized children with acute respiratory tract infection (ARTI) in a grade-A tertiary hospital in Yueyang City. Methods Clinical data and nasopharyngeal swabs were collected from children under 14 years of age who were hospitalized with ARTI in the above-mentioned hospital from July 2019 to June 2020. HMPV was detected by real-time polymerase chain reaction. The HMPV-positive samples were genotyped for M and F. The infection characteristics and genotyping features of HMPV in children with ARTI were analyzed. Results A total of 60 children patients with ARTI were positive for HMPV in 3,175 nasopharyngeal swabs detected, with a positive detection rate of 1.9%. The patients with HMPV infection ranged in age from 23 days to 8 years. The proportion of infants under 1 year old was 30.0% (18/60). Summer (57.7%) and autumn (36.7%) were predominant in the seasonal distribution, and no HMPV infection was detected in spring. Among the 60 children with HMPV infection, the main clinical diagnoses were bronchitis (65.0%, 39/60) and pneumonia (26.7%, 16/60), and the main clinical manifestations were fever (71.7%, 43/60) and cough (71.7%, 43/60). In the patients infected with HMPV, the HMPV A2b genotype accounted for 53.3%. Conclusion HMPV infection was most common in infants under 1 year old. The prevalence peak occurred in summer and autumn during the monitoring period. Bronchitis was the main diagnosis of the HMPV patients. The main prevalent strain was A2b type.
彭芬, 杨毅, 余飞跃, 姜习新. 岳阳市某院儿童急性呼吸道人偏肺病毒感染情况及基因特征分析[J]. 实用预防医学, 2023, 30(8): 936-939.
PENG Fen, YANG Yi, YU Feiyue, JIANG Xixin. Infection status and genetic characteristics of human metapneumovirus in children with acute respiratory tract infection in Yueyang City. , 2023, 30(8): 936-939.
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