Abstract：Objective To determine if homocysteine (Hcy) is an independent risk factor for carotid atherosclerosis in postmenopausal women. Methods Determination of serum Hcy and carotid artery ultrasound examination were performed in 1,204 postmenopausal women aged above 55 years and undergoing physical examination in Peking Union Medical College Hospital from December 2017 to December 2018. Multivariate logistic regression was used to analyze the impact of Hcy and other traditional risk factors on carotid atherosclerosis. Results The mean level of Hcy was (12.4±3.3) μmol/L, and 176(14.62%) women had hyperhomocysteinemia. Hcy was positively correlated with age(r=0.19, P<0.001)and body mass index (r=0.11, P<0.001). Serum Hcy levels of patients with carotid atherosclerosis significantly increased(Z=-2.56, P=0.011). Logistic regression analysis revealed that only age (OR=1.11, 95%CI:1.09-1.14)and systolic pressure (OR=1.02, 95%CI:1.01-1.02) were independent risk factor for carotid atherosclerosis, while age (OR=1.10, 95%CI:1.08-1.12), systolic pressure (OR=1.02, 95%CI:1.01-1.02), glycated hemoglobin (OR=1.27, 95%CI:1.07-1.50) and history of hypertension (OR=1.40, 95%CI:1.06-1.87) were independent risk factors for carotid plaque. Conclusions Hcy is not an independent risk factor for carotid atherosclerosis in postmenopausal women; and hence, the significance of screening of hyperhomocysteinemia in carotid atherosclerosis prevention among this population remains to be further demonstrated.
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2020, Vol. 27 
