Abstract：Objective To explore the relationship of sex hormone level with negative emotions in women with perimenopausal syndrome. Methods One hundred and four women with perimenopausal syndrome hospitalized in Suining Central Hospital from July 2018 to March 2022 were selected as the research subjects. Automatic biochemical analyzer was used to detect the levels of testosterone (T), luteinizing hormone (LH), progesterone (P), follicular stimulating hormone (FSH), estradiol (E2) and other estrogens. Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were employed to evaluate negative emotions. We evaluated the subjects’ expression levels of sex hormones and emotional scores, the expression levels of sexhormones in patients with different emotional scores, and the correlation between sex hormone levels and negative emotions. Results As for the 104 perimenopausal syndrome patients’ HAMD scores, there were 21 (20.19%) patients with normal score, 24 (23.08%) with mild depression, 44 (42.31%) with moderate depression, and 15 (14.42%) with severe depression. As for the 104 perimenopausal syndrome patients’ HAMA scores, there were 20 (19.23%) patients with normal score, 22 (21.15%) with mild anxiety, 46 (44.23%) with moderate anxiety, and 16 (15.38%) with severe anxiety. Serum levels of T and P showed statistically significant differences among groups with different levels of depression and anxiety (P<0.05). Serum level of T was higher in the severe depression group than in the normal group, while serum level of P was lower in the severe depression group than in the normal group (P<0.05). Serum level of T was higher in the severe anxiety group than in the normal group, whereas serum levels of P and E2 were lower in the severe anxiety group than the normal group (P<0.05). Pearson analysis revealed that serum T level was positively correlated with HAMD and HAMA scores (P<0.05), while serum P level was negatively correlated with HAMD and HAMA scores (P<0.05). Conclusion Serum T level of the patients with perimenopausal syndrome is positively related to HAMD and HAMA scores, but serum P level is inversely associated with HAMD and HAMA scores.
弋淑, 李念, 王旭. 围绝经期综合征女性性激素水平与负性情绪的关系研究[J]. 实用预防医学, 2023, 30(6): 704-706.
YI Shu, LI Nian, WANG Xu. Relationship between sex hormone level and negative emotions in women with perimenopausal syndrome. , 2023, 30(6): 704-706.
2023, Vol. 30 
