Abstract：Objective To explore the risk factors for type 2 diabetes mellitus patients complicated with osteoporosis so as to provide evidence for prevention and early diagnosis of type 2 diabetes mellitus complicated by osteoporosis. Methods According to their bone mineral density, 175 patients with type 2 diabetes mellitus hospitalized in the People’s Hospital of Maoming City from February 2012 to July 2015 were divided into osteoporosis group (n=80) and non-osteoporosis group (n=95). The clinical data, including age, gender, duration of diabetes, body mass index (BMI), serum phosphorus, glycosylated hemoglobin 1c (HbA1c) and alkaline phosphatase (ALP) were compared between the two groups. The correlations between the relevant factors and bone mineral density were analyzed by pearson correlation analysis. Results The bone mineral density was significantly lower in the osteoporosis group than in the non-osteoporosis group (0.82±0.17 g/cm vs. 1.25±0.12 g/cm, t=5.862, P<0.01). There were statistically significant differences in age (67.26±11.35 vs. 61.85±10.62 years old), duration of diabetes (10.44±10.13 vs. 7.03±3.45 years), BMI (24.38±3.51 vs. 26.82±4.89 kg/m2), fasting insulin (12.887±5.265 vs. 18.429±6.166 mIU/L), HbA1c(8.84±2.36% vs. 8.23±2.57%) and ALP (69.75±23.37 vs. 62.26±20.81 U/L) between the two groups (P<0.05). Pearson correlation analysis showed that age, duration of diabetes, HbA1c and ALP were negatively correlated with the bone mineral density (r=-0.753, r=-0.657, r=-0.587, r=-0.641, P<0.05), while BMI and fasting insulin were positively correlated with the bone mineral density (r=0.626, r=0.765, P<0.05). Conclusions Type 2 diabetes mellitus patients with advanced age, longer duration of diabetes, higher BMI, worse blood glucose control, higher ALP and higher HbA1c are at higher risk for osteoporosis; and hence, special attention should be paid to them.
2016, Vol. 23 
