Association of anthropometric indicators with death from cardiovascular and cerebrovascular diseases in elderly patients with type 2 diabetes mellitus: a prospective cohort study
FAN Yao1, GU Liubao1, WANG Lan2
1. Development of Clinical Epidemiology, Geriatric Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210024, China; 2. Geriatric Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210024, China
Abstract：Objective To explore the association between anthropometric indicators andrisk of death fromcardiovascular and cerebrovascular diseases (CCVD) in elderly patients with type 2 diabetes mellitus (T2DM). Methods Based on the Staged Diabetes Targeting Management (SDTM) Project of Geriatric Hospital Affiliated to Nanjing Medical University, prospective open cohort follow-up was adopted. The causes of CCVD deaths included myocardial infarction, angina pectoris, cerebral hemorrhage, cerebral ischemia and other cardiovascular diseases. Cox regression model was used to analyze the correlation between different anthropometric indicators and CCVD death risk. Results As of December 2019, a total of 4,285 patients with T2DM were dynamically followed up. Subjects with T1DM, aged less than 65 years and missing important baseline or outcome variables were excluded. Finally, a total of 917 subjects were included in this study. The average follow-up time of the subjects was (7.57±3.17) years, with a cumulative follow-up of 6,937.97 person years. During the follow-up period, the number of deaths due to CCVD was 46, and the death density was 66.30/10,000 person years. Cox proportional hazards regression analysis displayed that after adjusting for potential confounding factors, the elevated waist circumference-to-height ratio (WHtR) increased the risk of death from CCVD in the total population, with hazard ratio (HR) (95%CI) being 1.516 (1.107-2.076). The elevated WHtR increased the risk of death from CCVD in females and populations without dyslipidemia or hyperuricemia, with hazard ratios (HRs) (95%CIs) were 1.899 (1.179-3.059), 1.721 (1.016-2.918) and 1.671 (1.147-2.433) respectively. Conclusion The higher WHtR anthropometric indicator in the elderly population with T2DM increases the risk of death from CCVD. Among females and elderly T2DM populations without hyperlipidemia or hyperuricemia, higher WHtR is a high risk factor for death from CCVD.
樊垚, 顾刘宝, 王岚. 老年2型糖尿病患者身体测量指标与心脑血管死亡关联的前瞻性队列研究[J]. 实用预防医学, 2023, 30(8): 902-907.
FAN Yao, GU Liubao, WANG Lan. Association of anthropometric indicators with death from cardiovascular and cerebrovascular diseases in elderly patients with type 2 diabetes mellitus: a prospective cohort study. , 2023, 30(8): 902-907.
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2023, Vol. 30 
