Combined effect of hearing loss and diabetes on memory related diseases in Chinese middle-aged and elderly population
ZHOU Chensijia1, WANG Yan1, SHEN Ling1, ZHOU Juping2, FU Jiaojiao1
1. Suzhou Ninth People’s Hospital/ Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, Jiangsu 215000, China; 2. Wujiang District Center for Disease Control and Prevention, Suzhou, Jiangsu 215000, China
Abstract：Objective To investigate the combined impact of hearing loss and diabetes on the risk of memory related diseases in the middle-aged and elderly in China, and to provide references for the early prevention and treatment of memory related diseases. Methods Using the longitudinal follow-up data from China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018, a total of 12,711 individuals were included. According to the status of baseline hearing loss and diabetes, these subjects were divided into the group without hearing loss and diabetes, the group without hearing loss but with diabetes, the group with hearing loss but without diabetes and the group with hearing loss and diabetes. Cox proportional hazard models were used to analyze the combined effect of hearing loss and diabetes on memory related diseases. Results After an average follow-up of 6.1 years, a total of 285 cases of memory related diseases occurred.Taking individuals without hearing loss and diabetes as the control group, after adjusting for confounding factors, the hazard ratios (95%CI) of occurrence of memory related diseases in the group with hearing loss but without diabetes, the group without hearing loss but with diabetes and the group with hearing loss and diabetes were 1.81(1.22-2.68), 1.44(0.86-2.41) and 4.72(2.19-10.14) respectively. The results of subgroup analyses based on sex and BMI were consistent with the primary results. Conclusion Hearing loss combined with diabetes is associated with an increased risk of memory related diseases, suggesting that the monitoring of hearing and blood glucose in the middle-aged and elderly should be strengthened, which is helpful for the early prevention of memory related diseases.
周陈思嘉, 王燕, 沈玲, 周菊平, 付姣姣. 我国中老年人群听力损失和糖尿病对记忆类疾病的联合作用[J]. 实用预防医学, 2023, 30(11): 1333-1337.
ZHOU Chensijia, WANG Yan, SHEN Ling, ZHOU Juping, FU Jiaojiao. Combined effect of hearing loss and diabetes on memory related diseases in Chinese middle-aged and elderly population. , 2023, 30(11): 1333-1337.
[1] Burton EJ, Mckeith IG, Burn DJ, et al. Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls[J].Brain, 2004,127:791-800. [2] Clay E, Zhou J, Yi ZM, et al. Economic burden for Alzheimer's disease in China from 2010 to 2050: a modelling study[J].J Mark Access Health Policy, 2019,7(1):1667195. [3] 袁小楠,秦心睿,闻崇兵,等. 日光疗法对老年痴呆患者激越行为影响的meta分析[J].实用预防医学, 2023,30(2):144-147. [4] Jia LF,Du YF,Chu L,et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study[J].Lancet Public Health, 2020,5(12):E661-E671. [5] Walton C, King R, Rechtman L, et al.Rising prevalence of multiple sclerosis worldwide: insights from the Atlas of MS, third edition[J].Mult Scler, 2020,26(14):1816-1821. [6] Mak E, Su L, Williams GB, et al. Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study[J].Brain, 2015,138:2974-2986. [7] Livingston G, Huntley J, Sommerlad A, et al.Dementia prevention, intervention, and care: 2020 report of the Lancet Commission[J].Lancet, 2020,396(10248):413-446. [8] Johnson J, Marshall CR, Weil RS, et al.Hearing and dementia: from ears to brain[J].Brain, 2021,144(2):391-401. [9] Xue M, Xu W, Ou YN, et al.Diabetes mellitus and risks of cognitive impairment and dementia: a systematic review and meta-analysis of 144 prospective studies[J].Ageing Res Rev, 2019,55:100944. [10] Zhao Y, Hu Y, Smith JP, et al.Cohort profile: the China Health and Retirement Longitudinal Study(CHARLS)[J].Int J Epidemiol, 2014,43(1):61-68. [11] Xue Y, Liu G, Geng Q.Associations of cardiovascular disease and depression with memory related disease: a Chinese national prospective cohort study[J].J Affect Disord, 2020,260: 11-17. [12] 沈银, 骆雄, 唐牟尼, 等.简明精神状态检查和蒙特利尔认知评估量表筛查社区老年人中轻度认知功能障碍及痴呆的应用分析[J].中华精神科杂志, 2014,47(5):293-297. [13] Hung SC, Liao KF, Muo CH, et al.Hearing loss is associated with risk of Alzheimer's disease: a case-control study in older people[J].J Epidemiol, 2015,25(8):517-521. [14] 刁桐湘, 张季蕾, 陈妮姗, 等.年龄相关性听力损失与认知功能障碍[J].中华耳鼻咽喉头颈外科杂志, 2021,56(2):187-192. [15] Humes LE, Dubno JR, Gordon-Salant S, et al.Central presbycusis: a review and evaluation of the evidence[J].J Am Acad Audiol, 2012,23(8):635-666. [16] Gurgel RK, Ward PD, Schwartz S, et al.Relationship of hearing loss and dementia: a prospective, population-based study[J].Otol Neurotol, 2014,35(5):775-781. [17] Martini A, Castiglione A, Bovo R, et al. Aging, cognitive load, dementia and hearing loss[J].Audiol Neurootol, 2014,19: 2-5. [18] Tun PA, Mccoy S, Wingfield A. Aging, hearing acuity, and the attentional costs of effortful listening[J].Psychol Aging, 2009,24(3):761-766. [19] Su PJ, Hsu CC, Lin HC, et al. Age-related hearing loss and dementia: a 10-year national population-based study[J].Eur Arch Otorhinolaryngol, 2017,274(5):2327-2334. [20] Verghese J, Lipton RB, Katz MJ, et al.Leisure activities and the risk of dementia in the elderly[J].N Engl J Med, 2003,348(25):2508-2516. [21] 潘琦, 郭立新.《中国老年糖尿病诊疗指南(2021年版)》要览[J].中国医学前沿杂志(电子版), 2022,14(4):1-6. [22] Chohan H, Senkevich K, Patel RK, et al. Type 2 diabetes as a determinant of Parkinson's disease risk and progression[J].Mov Disord, 2021,36(6):1420-1429. [23] 汪璐璐,刘安诺,刘鸿雁,等. 2型糖尿病患者自我管理行为与认知功能各维度的关系研究[J].实用预防医学, 2020,27(1):1-4. [24] Xu WL, Caracciolo B, Wang HX, et al. Accelerated progression from mild cognitive impairment to dementia in people with diabetes[J].Diabetes, 2010,59(11):2928-2935. [25] 万婧, 王健, 尹训涛, 等. 2型糖尿病与痴呆亚型相关机制的研究进展[J].重庆医学, 2014,43(31):4247-4249. [26] Vagelatos NT,Eslick GD. Type 2 diabetes as a risk factor for Alzheimer's disease: the confounders, interactions, and neuropathology associated with this relationship[J].Epidemiol Rev, 2013,35:152-160. [27] Talbot K, Wang HY, Kazi H, et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline[J].J Clin Invest, 2012,122(4):1316-1338. [28] 郑洪赠, 蔡志良, 林庆强.糖尿病患者听力损失的临床特点分析[J].糖尿病新世界, 2017,20(18):62-63. [29] Rogers M, Langa KM.Untreated poor vision: a contributing factor to late-life dementia[J].Am J Epidemiol, 2010,171(6):728-735. [30] Chang L, Lowe J, Ardiles A, et al. Alzheimer's disease in the human eye.Clinical tests that identify ocular and visual information processing deficit as biomarkers[J].Alzheimers Dement, 2014,10(2):251-261. [31] Maselko J, Bates LM, Avendano M, et al.The intersection of sex, marital status, and cardiovascular risk factors inshaping stroke incidence: results from the health and retirement study[J].J Am Geriatr Soc, 2009,57(12):2293-2299. [32] Aguayo GA, Vaillant MT, Donneau AF, et al.Comparative analysis of the association between 35 frailty scores and cardiovascular events, cancer, and total mortality in an elderly general population in England: an observational study[J].PLoS Med, 2018,15(3):e1002543. [33] St Sauver JL, Hagen PT, Cha SS, et al.Agreement between patient reports of cardiovascular disease and patient medical records[J].Mayo Clin Proc, 2005,80(2):203-210.
2023, Vol. 30 
