Abstract：Objective To explore the incidence and risk factors of adverse reactions of anti-tuberculosis (anti-TB) drugs in new smear positive pulmonary tuberculosis patients. Methods Totally, 115 new smear positive pulmonary tuberculosis patients who received fixed-dose combination (FDC) treatment in Yuelu District, Changsha and Ningxiang County from October to December 2013 were recruited. The incidence of adverse reactions of anti-TB drugs that occurred in the course of treatment was monitored. Risk factors of adverse reactions were explored by univariate and multivariate analysis. Results Adverse reactions occurred in 43 out of 115 cases, with an incidence rate of 37.4%. The univariate analysis showed that the incidence of adverse reactions was significantly different among groups by age (Wald X2 = 6.436, P value = 0.040), education level (Wald X2 = 8.776, P = 0.032), body mass index (Wald X2 = 6.534, P value = 0.038), and drinking history (Wald X2 = 4.019, P = 0.045). Multivariate non-conditioned logistic regression analysis indicated that advanced age (Wald X2 = 14.337, P = 0.001), lower education level (Wald X2 = 16.042, P = 0.001) and drinking history (Wald X2 = 8.392, P = 0.004) were risk factors. ConclusionsThe incidence of adverse reactions of anti-tuberculosis drugs in the 115 new smear positive pulmonary tuberculosis patients is high. Advanced age, lower education level and drinking history can increase the incidence.
熊姿,白丽琼,李清香,彭瑶,潘林. 115例初治涂阳肺结核患者抗结核药物不良反应发生率及影响因素研究[J]. 实用预防医学, 2015, 22(5): 537-540.
XIONG Zi, BAI Li-qiong, WANG Xiao-jun, GONG De-hua, LI Qing-xiang, PENG Yao, PAN Lin. Study on the incidence and risk factors of adverse reactions of anti- tuberculosis drugs in 115 new smear positive pulmonary tuberculosis patients. , 2015, 22(5): 537-540.
2015, Vol. 22 
