Relationship between serum adiponectin level and nonalcoholic fatty liver disease in physical examination population
TAN Xiao1, DENG Juan2, ZHANG Li3
1. Dazhou Dachuan District People's Hospital (Dazhou Third People's Hospital), Dazhou, Sichuan 635000, China; 2. Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi 710032, China; 3. Dazhou Central Hospital, Dazhou, Sichuan 635000, China
Abstract：Objective To explore the correlation between serum adiponectin level and nonalcoholic fatty liver disease (NAFLD) amongst physical examination population so as to provide a reference basis for predicting and intervening NAFLD in clinical practice. Methods Four hundred and thirty subjects undergoing physical examination in Dazhou Dachuan District People's Hospital (Dazhou Third People's Hospital) from January 2021 to December 2022 were enrolled into this study. All the subjects' general data were collected, and then they underwent abdominal ultrasound examination and detection of blood biochemicalindicators (including fasting plasma glucose (FPG), fasting insulin (FINS), glycosylated hemoglobin (HbAlc), homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), adiponectin, aspartate aminotransferase (AST) and alanine aminotransferase (ALT)). Pearson correlation analysis was performed to explore the correlations of serum adiponectin with each clinical parameter and NAFLD.Receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of serum adiponectin on NAFLD, and multivariate logistic regression analysis was used to explore the risk factors affecting NAFLD occurrence. Results A total of 107 patients with NAFLD (the NAFLD group) and 323 subjects without NAFLD (the control group) were detected. The male ratio, body mass index (BMI), waist-to-hip ratio, systolic blood pressure, FPG, FINS, HbAlc, HOMA-IR, TC, TG, LDL, AST and ALT were all significantly higher in the NAFLD group than in the control group (all P<0.05), while serum adiponectin level was significantly lower in the NAFLD group than in the control group (P<0.05). Pearson correlation analysis revealed that serum adiponectin was negatively correlated with BMI, waist-to-hip ratio, FPG, FINS, HbAlc, HOMA-IR, TG and LDL (P<0.05). The area under the ROC curve of adiponectin in predicting NAFLD was 0.680 (P<0.05). Multivariate logistic regression analysis displayed that reduced adiponectin was an independent risk factor for NAFLD occurrence (OR=2.236, 95%CI:1.262-4.287, P<0.05). Conclusion Serum adiponectin is closely related to NAFLD occurrence, and detecting its level has a good value inpredicting NAFLD occurrence. It can be classified as a routine examination for physical examinees so as to help clinically predict NAFLD occurrence and perform early intervention.
2024, Vol. 31 
