Abstract：Objective To explore the relationship between leptin-adiponectin imbalance and metabolic syndrome in children and adolescents. Methods A total of 827 children and adolescents in a certain region in Hunan province were investigated. Physical examination and plasma index detection such as leptin, adiponectin and tumor necrosis factor were performed. We divided the subjects into four groups according to the number of metabolic syndrome (MS) components, compared the differences in theindexes detected among the groups, and then analyzed their relationships with MS and their components. Receiver operating characteristic curves were used to evaluate the diagnostic values of leptin, adiponectin and leptin/adiponectin (L/A) ratio in MS. Results The level of plasma leptin and L/A ratio were higher but adiponectin concentration was lower in children and adolescents with more MS components (χ2=79.08, χ2=85.88, χ2=28.66, all P<0.001). After adjusting for age and sex, MS was still positively correlated with leptin and L/A ratio, but negatively correlated with adiponectin. The correlation between MS and L/A ratio (0.350) was higher than that of leptin and adiponectin (0.333 and -0.208, respectively). Furthermore, in male and female children and adolescents, the area under curve (AUC) of L/A ratio for MS was larger than that of leptin or adiponectin, and was of certain diagnostic value. Conclusions Metabolic syndrome in children and adolescents is associated with leptin-adiponectin imbalance, and L/A ratio may be a better diagnostic biomarker for MS than leptin or adiponectin alone.
尹晓晨, 陈明, 龙晓蕾, 李梓民, 段雨劼, 易传祝. 瘦素-脂联素失衡与儿童青少年代谢综合征的关系研究[J]. 实用预防医学, 2020, 27(9): 1081-1085.
YIN Xiao-chen, CHEN Ming, LONG Xiao-lei, LI Zi-min, DUAN Yu-jie, YI Chuan-zhu. Association between leptin-adiponectin imbalance and metabolic syndrome in children and adolescents. , 2020, 27(9): 1081-1085.
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