Abstract：Objective To quantitatively evaluate the association between dietary vitamin C and metabolic syndrome (MetS) based on a meta-analysis, and to provide a basis for MetS prevention and treatment. Methods PubMed, EMBASE, CNKI, WanfangData and VIP databases were systematically searched for observational epidemiological studies on the association between dietary vitamin C and risk of MetS published from the establishment of the databases to December 2021. After the data extraction, a meta-analysis was performed with Stata 12.0. Results A total of 7 articles were enrolled in this analysis, involving 29,363 participants and 8,300 MetS patients. Meta-analysis results revealed that the group with the highest dietary vitamin C intake decreased the risk of MetS by 7% compared with the group with the lowest intake (RR=0.93, 95%CI:0.89-0.98). The dose-response meta-analysis showed a linear relationship between dietary vitamin C and the risk of MetS (non-linear P>0.10), with each 50 mg/d increase insignificantly reducing the risk of MetS (RR=0.97, 95%CI:0.92-1.02). Conclusion There is an association between MetS and dietary vitamin C intake amount, and high dietary vitamin C intake can reduce the risk of MetS.
[1] Sherling DH, Perumareddi P, Hennekens CH. Metabolic syndrome[J]. J Cardiovasc Pharmacol Ther, 2017,22(4):365-367. [2] Lemieux I, Després J. Metabolic syndrome: past, present and future[J]. Nutrients, 2020,12(11):3501. [3] 罗素芬, 晋学庆. 肾素-血管紧张素系统与代谢综合征研究进展[J]. 医学综述, 2009,15(3):464-466. [4] 周青, 王林俊, 陈丽, 等.南京市医务工作者代谢综合征流行状况及影响因素分析[J]. 实用预防医学, 2021,28(8):998-1001. [5] 曹霞. 基于网络科学的膳食摄入与代谢综合征的相关性研究[D]. 沈阳:中国医科大学, 2021. [6] 张美琳, 黄国伟. 膳食因素与高尿酸血症及代谢综合征关系研究进展[J]. 中国慢性病预防与控制, 2010,18(4):433-435. [7] 朱徐慧, 章荣华, 周标,等. 浙江省老年人膳食营养素与代谢综合征的关系[J]. 中国老年学杂志, 2018,38(8):2009-2012. [8] Stang A. Critical evaluation of the Newcastle-Ottawa Scale for the assessment of the quality of nonrandomized studies in meta-analyses[J]. Eur J Epidemiol, 2010,25(9):603-605. [9] Herzog R,álvarez-Pasquin MJ,Díaz C,et al. Are healthcare workers' intentions to vaccinate related to their knowledge, beliefs and attitudes? A systematic review[J]. BMC Public Health, 2013,13: 154. [10] Zhang J, Yu KF. What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes.[J]. JAMA, 1998,280(19):1690-1691. [11] Bekkering GE, Harris RJ, Thomas S, et al. How much of the data published in observational studies of the association between diet and prostate or bladder cancer is usable for meta-analysis?[J]. Am J Epidemiol, 2008,167(9):1017-1026. [12] Vanderweele TJ. Optimal approximate conversions of odds ratios and hazard ratios to risk ratios[J]. Biometrics, 2020,76(3):746-752. [13] Greenland S, Longnecker MP. Methods for trend estimation from summarized dose-response data, with applications to meta-analysis[J]. Am J Epidemiol ,1992, 135(11):1301-1309. [14] Orsini N,Li R,Wolk A,et al. Meta-analysis for linear and nonlinear dose-response relations: examples, an evaluation of approximations, and software[J]. Am J Epidemiol, 2012,175(1):66-73. [15] de Oliveira Otto MC, Alonso A, Lee D, et al. Dietary intakes of zinc and heme iron from red meat, but not from other sources, are associated with greater risk of metabolic syndrome and cardiovascular disease[J]. J Nutr, 2012,142(3):526-533. [16] Kim MH,Lee HS,Park HJ,et al. Risk factors associated with metabolic syndrome in Korean elderly[J]. Ann Nutr Metab, 2007,51(6):533-540. [17] Li Y, Guo H, Wu M, et al. Serum and dietary antioxidant status is associated with lower prevalence of the metabolic syndrome in a study in Shanghai, China[J]. Asia Pac J Clin Nutr, 2013,22(1):60-68. [18] Wei J,Zeng C,Gong Q,et al. Associations between dietary antioxidant intake and metabolic syndrome[J]. PLoS One, 2015,10(6):e130876. [19] Kim J, Choi Y. Physical activity, dietary vitamin C, and metabolic syndrome in the Korean adults: the Korea National Health and Nutrition Examination Survey 2008 to 2012[J]. Public Health, 2016,135:30-37. [20] 顾秀瑛. 新疆哈萨克族膳食因素与代谢综合征的关系研究[D]. 石河子:石河子大学, 2014. [21] 胡浙芳, 丁钢强, 章荣华, 等. 浙江省城市居民膳食营养素与代谢综合征关系研究[J]. 营养学报, 2014,36(1):17-21. [22] 辛鹏, 李昌昆, 范莉莉, 等. 膳食营养与机体免疫力[J]. 职业与健康, 2021,37(13):1846-1851. [23] Granger M, Eck P. Dietary vitamin C in human health[J]. Adv Food Nutr Res, 2018,83:281-310. [24] 李娜, 张志强, 马强, 等. 维生素D水平与代谢综合征的meta分析[J]. 医药论坛杂志, 2018,39(8):73-78. [25] Wong SK, Chin K, Ima-Nirwana S. Vitamin C: a review on its role in the management of metabolic syndrome[J]. Int J Med Sci, 2020,17(11):1625-1638. [26] Bhattacharyya A, Chattopadhyay R, Mitra S, et al. Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases[J]. Physiol Rev, 2014,94(2):329-354. [27] Karam BS, Chavez-Moreno A, Koh W, et al. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes[J]. Cardiovasc Diabetol, 2017,16(1):120. [28] Chakraborthy A, Ramani P, Sherlin HJ, et al. Antioxidant and pro-oxidant activity of vitamin C in oral environment[J]. Indian J Dent Res, 2014,25(4):499-504. [29] Carr AC, Maggini S. Vitamin C and immune function[J]. Nutrients, 2017,9(11):1211.
2022, Vol. 29 
