Abstract：Objective To explore the association of adipocytokines and other indexes with overweight and obesity in children and adolescents. Methods Height, weight, blood pressure, fasting plasma glucose, blood lipid, fasting insulin, leptin, adiponectin, tumor necrosis factor-α1 (TNF-α), insulin-like growth factor 1 (IGF-1) and other indicators of 827 children and adolescents were measured, the differences between the overweight and obesity group and the normal control group were compared, and their correlation with overweight and obesity were analyzed. Results The prevalence rates of insulin resistance, elevated blood pressure and dyslipidemia in the overweight and obese children and adolescents were all higher than those in the normal control group. After adjusting for gender and age staging, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure(DBP), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), leptin and TNF-α levels of the overweight and obese children and adolescents were still higher than those of the normal control group, and presented a positive correlation with BMI (r=0.419, r=0.304, r=0.249, r=0.151, r=0.148, r=0.432, r=0.157). The content of high density lipoprotein cholesterol (HDL-C) and adiponectin in the overweight and obese children and adolescents was lower than that in the normal controls, and presented a negative correlation with BMI (r=-0.112, r=-0.182). The differences and correlation were statistically significant (all P<0.05). Multiple linear regression analysis showed that the regression equation composed of factors like leptin, TNF-α, SBP, IGF-1 and age could explain 51.2% of BMI variation (F=172.440,P<0.001). ConclusionsOverweight and obese children and adolescents are more likely to occur insulin resistance, elevated blood pressure, dyslipidemia and other changes. Leptin, TNF-α and IGF-1 are associated with overweight and obesity of children and adolescents, which may be involved in the occurrence and development of overweight and obesity.
陈明, 尹晓晨, 段雨劼, 李梓民, 龙晓蕾, 易传祝. 儿童青少年脂肪细胞因子等指标与超重和肥胖关系研究[J]. 实用预防医学, 2020, 27(10): 1163-1167.
CHEN Ming, YIN Xiao-chen, DUAN Yu-jie, LI Zi-min, LONG Xiao-lei, YI Chuan-zhu. Relationship of adipocytokines and other indexes with overweight and obesity in children and adolescents. , 2020, 27(10): 1163-1167.
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2020, Vol. 27 
