Relationship between the changes of serum HIF-1α, ET-1, uric acid and visfatin levels in pregnant women with gestational diabetes mellitus and neonatal Apgar score and birth weight
XU Guang-ping1, ZHENG Chun-lan2, BAI Lu-zeng1, LI Zhe1, DING Ya-qiong1
1.Nanyang Oilfield General Hospital, Nanyang, Henan 473000, China; 2.Huiji District of First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450044, China
Abstract：Objective To explore the changes of serum hypoxia-inducible factor alpha (HIF-1α), endothelin-1(ET-1), uric acid and visfatin levels in pregnant women with gestational diabetes mellitus (GDM) and their correlation with neonatal Apgar score and body weight. Methods One hundred and fifty GDM pregnant women (the GDM group) and 150 normal pregnant women (the control group) were selected from January 2016 to June 2017. The maternal serum levels of HIF-1α, ET-1, uric acid and alfatin at the 24-28 weeks of gestation were detectedand compared between the two groups. All pregnant women were followed up until the end of pregnancy. The neonatal outcomes of the two groups were observed, and the relationship between the above-mentioned indexes and neonatal outcomes was explored. Results The maternal serum levels of HIF-1α, ET-1, uric acid and alfatin at 24-28 weeks of gestation were significantly higher in the GDM group than in the control group, showing statistically significant differences (all P<0.05). No statistically significant differences were observed in the mode of delivery and the incidence rate of premature rupture of membranes between the two groups (both P>0.05). Pregnancy weeks and the 1-min Apgar score were significantly lower in the GDM group than in the control group (both P<0.05), while neonatal birth weight was higher in the GDM group than in the control group (P<0.05). The maternal serum levels of HIF-1α and ET-1 in the GDM group were negatively correlated with the 1-min Apgar score (P<0.05), whereas the maternal serum levels of uric acid and visfatin in the GDM group were positively correlated with neonatal birth weight (P<0.05). Conclusions Serum HIF-1α, ET-1, uric acid and visfatin levels of the GDM pregnant women are all increased; moreover, they are closely related to neonatal Apgar score and birth weight.
徐广萍, 郑春兰, 白录增, 李哲, 丁亚琼. GDM母体血清HIF-1α、ET-1、尿酸、内脂素的变化与新生儿Apgar评分、体质量的关系[J]. 实用预防医学, 2019, 26(1): 68-70.
XU Guang-ping, ZHENG Chun-lan, BAI Lu-zeng, LI Zhe, DING Ya-qiong. Relationship between the changes of serum HIF-1α, ET-1, uric acid and visfatin levels in pregnant women with gestational diabetes mellitus and neonatal Apgar score and birth weight. , 2019, 26(1): 68-70.
2019, Vol. 26 
