Abstract：Objective To investigate the effect of maternal serum hepatitis B virus surface antibody (anti-HBs) level on the immune response of their infants towards hepatitis B vaccine. Methods One hundred and nine infants aged 8-24 months injected with hepatitis B vaccine according to the standard immnunization program and hospitalized and born full-term in the Department of Pediatrics of Binzhou People’s Hospital from January 2014 to December 2015 were enrolled in this study. The quantitative detection results of the anti-HBs concentration in sera of the infants and mothers were analyzed. Results Among the 56 infants with maternal anti-HBs < 10 mIU/ml and negative HBsAg, 6 infants (10.71%) did not have immune response after injection of hepatitis B vaccine, and 50 (89.29%) had, with the median (95%CI) of serum anti-HBs level of 411.39 mIU/ml( 58.81 mIU/ml, 1,435.81 mIU/ml) . Among the 53 infants with maternal anti-HBs ≥10 mIU/ml, 1 infant (1.89%) did not have immune response, and 52 (98.11%) had, with the median (95%CI) of serum anti-HBs level of 457.11 mIU/ml(114.54 mIU/ml,1,475.49 mIU/ml). No statistically significant difference was found in the infants’ immune response rate to hepatitis B vaccine (χ2=3.618, P=0.308) as well as in the serum anti-HBs level (Z=-0.485, P=0.628) between the two infant groups with different levels of maternal anti-HBs. Whichever the serum level of maternal anti-HBs was (<10 mIU/ml or ≥10 mIU/ml), the serum level of anti-HBs was significantly lower in infants aged 16-24 months than in those aged 8-16 months (Z=-4.437, Z=-3.742, both P=0.000). But no statistically significant difference was found in the serum anti-HBs level among infants aged 8-16 months (Z=-0.496, P=0.620) as well as among infants aged 16-24 months (Z=-0.881, P=0.378) between the two maternal groups. As for infants with the serum maternal anti-HBs ≥10 mIU/ml, there was no correlation in the serum anti-HBs level between infants and mothers (r=-0.046, P=0.746). Conclusion The maternal serum anti-HBs level has no effects on the immune response of infants injected with hepatitis B vaccine according to the standard immunization program.
郭山春,康丽娟,李宝强,李艳飞,徐传伟. 母体血清抗-HBs水平对婴儿乙肝疫苗接种免疫应答的影响[J]. 实用预防医学, 2017, 24(4): 390-393.
GUO Shan-chun, KANG Li-juan, LI Bao-qiang, LI Yan-fei, XU Chuan-wei. Effect of maternal serum anti-HBs level on infants’ immune response to hepatitis B virus vaccine. , 2017, 24(4): 390-393.
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2017, Vol. 24 
