Effect of the time of measles vaccination before pregnancy in women of childbearing age on the measles antibody levels of their infants aged within 8 months
WANG Ye-zi, ZHENG Jian-rong, LIN Yuan-mei, WU Xiao-bing, LIANG Chi-bo, LIU Sai, ZHU Yong-mei, WEN Shi-xian
Community Health Service Center of Chang’an County, Dongguan, Guangdong 523880, China
Abstract：Objective To explore the influence of the time of measles vaccination before gregnancy in women of childbearing age on the measles antibody levels of their infants under 8 month of age. Methods A total of 976 women of childbearing age who received premarital health check in Chang’an Hospital of Dongguan City and Community Health Service Center of Chang’an County from January 2013 to May 2015 were selected to serve as the observation objects. According to measles vaccination at the different time points, all the women were divided into the group I (vaccinated 3-6 months before pregnancy), the group II (vaccinated 7-12 months before pregnancy) and the group III (vaccinated >12 months before pregnancy). Serum samples of the pregnant women were collected before vaccination, one month after vaccination and during childbirth, and umbilical cord blood samples also collected in the process of giving birth. The IgG antibody levels of measles were determined. We analyzed and compared the changes and differences in the IgG antibody levels of measles, the positive rates of measles IgG antibody and the positive rates of protective antibody before vaccination and one month after vaccination among the three groups. We also analyzed the correlation between the positive rate of measles IgG, the positive rate of protective antibody and the geometric mean concentration (GMC) in the mothers and their infants. Results We collected the data about 630 pregnant women who were eligible and had successful delivery from the three groups (each n=210). No statistically significant differences were found in the IgG antibody levels of measles, the positive rates of measles IgG antibody and the positive rates of protective antibody before vaccination and one month after vaccination among pregnant women in the three groups (all P>0.05). The IgG antibody level of measles, the positive rate of measles IgG antibody and the positive rate of protective antibody one month after vaccination in each group were all increased significantly as compared with those before vaccination (all P<0.05). The positive rate of measles IgG antibody during childbirth showed statistically significant differences among mothers and their newborns of the three groups (P<0.05). Pairwise comparison revealed that the differences in the positive rates of measles IgG antibody and the positive rates of protective antibody of mothers and their newborns from the groups I and II were significantly higher than those of the group III (P<0.017). The GMC of the newborns was increased with the elevated GMC of their mothers, and there was a positive correlation between them (Pearson correlation coefficient=0.999, P=0.020). Conclusions Measles vaccination within 3-12 months before pregnancy in women of childbearing age can significantly improve the measles antibody level of infants.
王叶子, 郑坚荣, 林苑梅, 吴晓冰, 梁赤波, 刘赛, 朱咏梅, 温世贤. 育龄妇女孕前接种麻疹疫苗时间对8月龄内婴儿麻疹抗体水平效果分析[J]. 实用预防医学, 2017, 24(9): 1075-1078.
WANG Ye-zi, ZHENG Jian-rong, LIN Yuan-mei, WU Xiao-bing, LIANG Chi-bo, LIU Sai, ZHU Yong-mei, WEN Shi-xian. Effect of the time of measles vaccination before pregnancy in women of childbearing age on the measles antibody levels of their infants aged within 8 months. , 2017, 24(9): 1075-1078.
2017, Vol. 24 
