Abstract：Objective To analyze the attenuation of HBsAb titers in preschoolers receiving vaccination against hepatitis B virus (HBV) at 0, 1 and 6 months of age, and to explore the earliest boosting age of HBV vaccine so as to provide relative evidence for scientifically formulating the strategies for booster immunization. Methods Enzyme linked immunosorbent assay (ELISA) was used to detect hepatitis B virus serological markers in 1,431 children aged from 18 months to 7 years in Xiangyang City. The earliest age of attenuation of HBsAb titer was calculated through analyzing the positive rate of HBsAb in uninfected children at different ages. Results Among the 1,431 urban children surveyed in Xiangyang City, the full course vaccination rate of HBV vaccine was 100% and the timely inoculation rate of the first injection was 98%. Among 59 children with HBV carrier mothers, 56 were prevented from HBV infection and 3 (0.2%) were in different phages of HBV infection. Along with the increase of age, thepositiverate of HBsAb was decreased significantly, 90.3% for 18m-<2y, 48.6% for 2-<3y, 49.7% for 3-<4y, 52.7% for 4-<5y, 44.3% for 5-<6y and 40.8% for 6-<7y (χ2 trend=118.61, P=0.000). The positive rate of HBsAb was significantly higher in children with timely inoculation of the first injection than in those without (χ2=5.798, P=0.0189). No statistically significant differences were found in the positive rate of HBsAb among children with different genders, with different doses of hepatitis B vaccine and with or without HBV carrier mothers (all P>0.05). Conclusions The positive rate of HBsAb can be increased by timely inoculation of the first injection of HBV vaccine in neonates. The positive rate of HBsAb in children with the 3-dose primary vaccination course of HBV vaccine is significantly decreased with the increase of age; and hence, it is necessary to perform HBV serological test in children at the age of 2-3 years and boost HBV vaccination in time. It is strategically recommended to boost HBV vaccination in children aged 2 years and above.
鲍春,陈德黎,王秀华,司谦,潘攀. 儿童乙型肝炎病毒疫苗免疫效果监测及强化免疫最小年龄探讨[J]. 实用预防医学, 2017, 24(4): 394-396.
BAO Chun, CHEN De-li, WANG Xiu-hua, SI Qian, PAN Pan. Surveillance on effectiveness of hepatitis B virus vaccination in children anddiscussion on the earliest boosting age. , 2017, 24(4): 394-396.
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