Abstract:Objective To synthetically evaluate the risk factors associated with the incidence of tuberculosis in China so as to provide evidence for conducting effective intervention measures. Methods We retrieved the studies by searching risk factor, tuberculosis and other terms in Pubmed/Medline, EMBASE, CNKI and other databases, screened the studies according to the inclusion and exclusion criteria, and then extracted the related data. Review Manager 5.3 software was used to perform meta-analysis. Results Twenty-two studies and 11,004 objects were included in this study. Meta-analysis showed that factors as tuberculosis contact history(pooled OR values, OR=3.13, 95%CI:2.73-3.60), low body mass index (BMI) (OR=2.93, 95%CI:1.78-4.82), smoking(OR=1.72, 95%CI:1.39-2.12), high labor intensity(OR=2.29, 95%CI:1.80-2.90), drinking(OR=1.29, 95%CI:0.93-1.79), low income(OR=1.73, 95%CI:1.41-2.12), much interpersonal communication(OR=1.96, 95%CI:1.65-2.33), poor housing conditions(OR=1.16, 95%CI:1.10-1.23), negative life events(OR=1.92, 95%CI:1.09-3.39), low awareness of tuberculosis(OR=2.07, 95%CI:1.68-2.54), BCG (bacille Calmette-Guerin) scar(OR=0.35, 95%CI:0.25-0.50), BCG vaccination history(OR=0.60, 95%CI:0.47-0.76), high education level(OR=0.58, 95%CI:0.51-0.65), physical exercise(OR=0.35, 95%CI:0.14-0.87), families with tuberculosis patients (OR=2.12, 95%CI:1.54-2.93)were associated with the incidence of tuberculosis. Conclusions The factors as tuberculosis contact history, low BMI, smoking, high labor intensity, low income, much interpersonal communication, negative life events, low awareness of tuberculosis and families with tuberculosis patients are closely related to the incidence of tuberculosis; and hence, effective health intervention against the above-mentioned factors should be carried out in the high-risk population of tuberculosis.
杨凯璇, 费丽萍, 寇新荣, 韩松, 张莹. 中国15岁以上人群结核病发病危险因素meta分析[J]. 实用预防医学, 2018, 25(1): 3-6.
YANG Kai-xuan, FEI Li-ping, KOU Xin-rong, HAN Song, ZHANG Ying. Meta-analysis on risk factors related to the incidence of tuberculosis in Chinese population aged 15 years and above. , 2018, 25(1): 3-6.