Abstract：The pathogenesis of lung cancer is related to the malignant transformation of lung tissue cells induced by carcinogens in cigarette smoke, but the individuals' dissimilar abilities to metabolize these carcinogens make the prevalence of lung cancer different in smoking population, and human genetic polymorphism plays a key role in the carcinogenic effect of cigarette carcinogens. Studies have shown that genes related to smoking population are significantly associated with lung cancer susceptibility. Gene mutations like CYP450, GSTs, ERCC1, CHRNA5, EGFR and FHIT can increase the risk of lung cancer in smoking population. By clarifying the role mechanism of involvement of relevant genes in the occurrence and development of lung cancer and their impacts on chemotherapy drug resistance, it will help guide clinical rational drug use. This study reviews the relationships of genes related to smoking population with the occurrence and development of lung cancer so as to provide new ideas for lung cancer prevention and treatment in smoking population.
段依霜. 吸烟人群相关基因与肺癌发生发展的综述[J]. 实用预防医学, 2024, 31(3): 380-385.
DUAN Yishuang. Review on genes related to smoking population and occurrence and development of lung cancer. , 2024, 31(3): 380-385.
[1] 程传龙,韩闯,房启迪,等. 基于时空地理加权回归模型探索肺癌发病的环境影响因素[J]. 山东大学学报(医学版),2023,61(4):95-102. [2] Schuller HM. The impact of smoking and the influence of other factors on lung cancer[J]. Expert Rev Respir Med, 2019,13(8):761-769. [3] Ryu CS, Choi YJ, Nam HS, et al. Short-term regulation of the hepatic activities of cytochrome P450 and glutathione S-transferase by nose-only cigarette smoke exposure in mice[J]. Food Chem Toxicol, 2019,125(1):182-189. [4] 解宝泉,黄艳,张志艳,等. 烟碱型乙酰胆碱受体亚单位a5基因多态性与吸烟老年人肺癌的关系[J]. 中国老年学杂志,2018,38(14):3377-3380. [5] 邹晨曦,徐轶,韩盈盈,等. 吸烟对驱动基因阴性非小细胞肺癌患者免疫检查点抑制药疗效的影响[J]. 中国临床药理学杂志,2023,39(10):1397-1401. [6] Shang Y,Li X,Liu W,et al. Comprehensive genomic profile of Chinese lung cancer patients and mutation characteristics of individuals resistant to icotinib/gefitinib[J]. Sci Rep, 2020,10(1):20243. [7] 中国疾病预防控制中心. 2018中国成人烟草调查内容摘要[EB/OL]. (2019-08-14) [2021-12-20]. https://www.chinac-dc.cn/jkat/sthd_3844/slhd_12885/201908/120190814_204616.html. [8] 戴晓,董志君. 2016—2019年慈溪地区40岁以上人群呼吸系统疾病死亡与烟草暴露的相关性分析[J]. 实用预防医学,2021,28(1):15-19. [9] Tang MS, Wu XR, Lee HW, et al. Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice[J]. Proc Natl Acad Sci, 2019,116(43):21727-21731. [10] 丁贤彬,吕晓燕,焦艳,等. 2019年重庆市30岁及以上人群归因于被动吸烟的肺癌疾病负担研究[J]. 实用预防医学,2022,29(8):911-915. [11] 高兴洪,唐红梅,李月蛟,等. 转位蛋白配体XBD173对香烟烟雾提取物诱导小鼠肺炎症反应的减轻作用及其机制[J]. 吉林大学学报(医学版),2023,49(2):272-279. [12] Hou W, Hu S, Li C, et al. Cigarette smoke induced lung barrier dysfunction, EMT, and tissue remodeling: a possible link between COPD and lung cancer[J]. Biomed Res Int, 2019,2019(1):2025636. [13] He H, He MM, Wang H, et al. In utero and childhood/adolescence exposure to tobacco smoke, genetic risk, and lung cancer incidence and mortality in adulthood[J]. Am J Respir Crit Care Med, 2023,207(2):173-182. [14] Tindle HA,Stevenson Duncan M,Greevy RA,et al. Lifetime smoking history and risk of lung cancer: results from the framingham heart study[J]. J Natl Cancer Inst, 2018,110(11):1201-1207. [15] Rojewski AM,Tanner NT,Dai L,et al. Tobacco dependence predicts higher lung cancer and mortality rates and lower rates of smoking cessation in the national lung screening trial[J]. Chest,2018,54(1):110-118. [16] 王元达. 肺癌患者胸腔镜术后发生心肺并发症的相关影响因素分析[J]. 实用癌症杂志,2023,38(1):172-174. [17] Delijewski M,Bartoń A,Delijewska P,et al. Genetically determined metabolism of nicotine and its clinical significance[J]. Acta Biochim Pol, 2019,66(4):375-381. [18] Li M, Li A, He R, et al. Gene polymorphism of cytochrome P450 significantly affects lung cancer susceptibility[J]. Cancer Med, 2019,8(10):4892-4905. [19] 周晓玲,姚 迪. 恩施地区吸烟人群P450和GST基因多态性与肺癌易感性研究[J]. 国际检验医学杂志,2022,43(17):2152-2155. [20] He Q,Wang L,Zhang J,et al. CYP2E1 and GSTM1 gene polymorphisms, environmental factors, and the susceptibility to lung cancer[J]. J Clin Lab Anal, 2018,32(6):e22403. [21] Bray MJ, Chen LS, Fox L, et al. Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: a focus on nicotinic receptors and nicotine metabolizing enzyme[J]. Genet Epidemiol, 2020,44(7):748-758. [22] Boysen G, Arora R, Degner A, et al. Effects of GSTT1 genotype on the detoxification of 1,3-butadiene derived diepoxide and formation of promutagenic DNA-DNA cross-links in human hapmap cell lines[J]. Chem Res Toxicol, 2021,34(1):119-131. [23] Forghanifard MM,Aarabi A,Nasiri Aghdam M,et al. GSTs polymorphisms are associated with epigenetic silencing of CDKN2A gene in esophageal squamous cell carcinoma[J]. Environ Sci Pollut Res Int, 2020,27(25):31269-31277. [24] Cano M,Reynaga DD,Belluzzi JD,et al. Chronic exposure to cigarette smoke extract upregulates nicotinic receptor binding in adult and adolescent rats[J]. Neuropharmacology, 2020,181(1):108308. [25] Burbank AJ,Vadlamudi A,Mills KH,et al. The glutathione-S-transferase mu-1 null genotype increases wood smoke-induced airway inflammation[J]. J Allergy Clin Immunol, 2019,143(6):2299-2302. [26] Ritambhara,Tiwari S,Vijayaraghavalu S,et al. Genetic polymorphisms of xenobiotic metabolizing genes (GSTM1, GSTT1, GSTP1), gene-gene interaction with association to lung cancer risk in North India: a case control study[J]. Asian Pac J Cancer Prev, 2019,20(9):2707-2714. [27] El-Deek SEM,Abdel-Ghany SM,Hana RS,et al. Genetic polymorphism of lysyl oxidase, glutathione S-transferase M1, glutathione-S-transferase T1, and glutathione S-transferase P1 genes as risk factors for lung cancer in Egyptian patients[J]. Mol Biol Rep, 2021,48(5):4221-4232. [28] Pathak AK, Husain N, Kant S, et al. Independent and interactive effect of CYPs and GSTs genetic variants and tobacco smoking on the risk of non-small cell lung carcinoma[J]. Arch Med Res, 2021,52(7):719-730. [29] Lan X, Li Y, Wu Y, et al. The association of ERCC1 and ERCC5 polymorphisms with lung cancer risk in Han Chinese[J]. J Cancer, 2022,13(2):517-526. [30] Anoushirvani AA,Aghabozorgi R,Ahmadi A,et al. The relationship between rs3212986C>A polymorphism and tumor stage in lung cancer patients[J]. Cureus, 2019,11(4):e4423. [31] 吕鹏飞,周 静,朱瑞楠,等. ERCC1基因C8092A多态性与肺癌遗传易感性的关联研究[J]. 安徽医科大学学报,2021,56(3):458-461. [32] Grenda A, Blach J, Szczyrek M, et al. Promoter polymorphisms of TOP2A and ERCC1 genes as predictive factors for chemotherapy in non-small cell lung cancer patients[J]. Cancer Med, 2020,9(2):605-614. [33] Zhu P, Kang G, Jiao Y, et al. The α5-nAChR/PD-L1 axis facilitates lung adenocarcinoma cell migration and invasion[J]. Hum Cell, 2022,35(4):1207-1218. [34] Wang Z,Liu B,Zhu J,et al. Nicotine-mediated autophagy of vascular smooth muscle cell accelerates atherosclerosis via nAChRs/ROS/NF-κB signaling pathway[J]. Atherosclerosis, 2019,284(1):1-10. [35] Thorgeirsson TE, Geller F, Sulem P, et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease[J]. Nature, 2008,452(7187):638-642. [36] Chaity NI, Sultana TN, Hasan MM, et al. Nicotinic acetylcholine gene cluster CHRNA5-A3-B4 variants influence smoking status in a Bangladeshi population[J]. Pharmacol Rep, 2021,73(2):574-582. [37] 李琴,张亚雷,江梅,等. 吸烟和CHRNA5-A3-B4基因簇上rs588765位点多态性与肺癌的关联[J]. 中华疾病控制杂志,2015,19(1):1-4. [38] Riess JW, Gandara DR, Frampton GM, et al. Diverse EGFR exon 20 insertions and co-occurring molecular alterations identified by comprehensive genomic profiling of NSCLC[J]. J Thorac Oncol, 2018,13(10):1560-1568. [39] 欧阳彬,张卫东,李秀英,等. 非小细胞肺癌EGFR基因突变及PD-L1表达相关性分析[J]. 实用预防医学,2021,28(12):1498-1502. [40] 汪园园,刘希,柯璟,等. 吸烟与非小细胞肺癌EGFR基因突变状态的关系[J]. 临床与实验病理学杂志,2019,35(5):539-543. [41] Cheng FJ, Chen CH, Tsai WC, et al. Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC[J]. Oncogene, 2021,40(6):1162-1175. [42] Fuemmeler BF, Dozmorov MG, Do EK, et al. DNA methylation in babies born to nonsmoking mothers exposed to secondhand smoke during pregnancy: an epigenome-wide association study[J]. Environ Health Perspect, 2021,129(5):57010. [43] 张军,田大力,姜又红,等. 肺癌中FHIT基因缺失与吸烟关系的探讨[J]. 中国医科大学学报,2000,29(4):281-282. [44] 苏志刚,刘玉萍,韦晔,等. 香烟烟雾处理对BEAS-2B细胞FHIT基因甲基化及其mRNA表达的影响[J]. 毒理学杂志,2016,30(1):22-26. [45] Dutkowska A,Antczak A,Domańska-Senderowska D,et al. Expression of selected miRNA, RARβ and FHIT genes in BALf of squamous cell lung cancer (squamous-cell carcinoma, SCC) patients: a pilot study[J]. Mol Biol Rep, 2019,46(6):6593-6597. [46] 亢春彦,张秀芝,王丹丹,等. 基于肺癌患者8个抑癌基因启动子CPG岛甲基化构建人工神经网络筛查模型[J]. 中华肿瘤防治杂志,2020,27(21):1718-1724. [47] 刘月红,蒋军红. 非小细胞肺癌患者EGFR、ALK基因突变及临床病理特征与预后的相关性研究[J]. 临床肺科杂志,2020,25(5):760-763. [48] 张居洋,曹生亚,李文广,等. 基于流行病学资料及基因单核苷酸多态性的肺癌预测模型的建立[J]. 东南大学学报(医学版),2019,38(5):854-858. [49] Kawahara B, Faull KF, Janzen C, et al. Carbon monoxide inhibits cytochrome P450 enzymes CYP3A4/2C8 in human breast cancer cells, increasing sensitivity to paclitaxel[J]. J Med Chem, 2021,64(12):8437-8446. [50] Li L,Wang T,Hu M,et al. Metformin overcomes acquired resistance to EGFR TKIs in EGFR-Mutant lung cancer via AMPK/ERK/NF-κB signaling pathway[J]. Front Oncol, 2020,10(1):1605.
2024, Vol. 31 
