Abstract：Due to the development of social economy and the improvement of people's living conditions, the number of obese patients is increasing, which poses a serious threat to public health and public health services. This article reviews the relationship between oral flora and obesity, summarizes the mechanismleading toobesity from the aspects of oral flora affecting taste sensitivity, inducing inflammatory response, regulating host metabolism, and changing intestinal flora, and aims to provide new ideas for obesity prevention and treatment.
宋小健, 梁程红, 王丽敏, 袁慧娟. 口腔菌群与肥胖相关性的研究进展[J]. 实用预防医学, 2024, 31(1): 125-128.
SONG Xiaojian, LIANG Chenghong, WANG Limin, YUAN Huijuan. Research progress on the correlation between oral flora and obesity. , 2024, 31(1): 125-128.
[1] Malik VS,Willet WC,Hu FB. Nearly a decade on - trends, risk factors and policy implications in global obesity[J]. Nat Rev Endocrinol, 2020, 16(11):615-616. [2] Wang L, Zhou B, Zhao Z, et al. Body-mass index and obesity in urban and rural China: findings from consecutive nationally representative surveys during 2004-2018[J]. Lancet,2021, 398(10294):53-63. [3] Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013[J]. Lancet, 2014, 384(9945):766-781. [4] 陈明, 尹晓晨, 段雨劼, 等. 儿童青少年脂肪细胞因子等指标与超重和肥胖关系研究[J]. 实用预防医学, 2020, 27(10):1163-1167. [5] Endalifer ML,Diress G. Epidemiology, predisposing factors, biomarkers, and prevention mechanism of obesity: a systematic review[J]. J Obes, 2020, 2020: 6134362. [6] Fan Y, Pedersen O. Gut microbiota in human metabolic health and disease[J]. Nat Rev Microbiol, 2021, 19(1):55-71. [7] 龚萍, 朱齐凤, 尹洁云,等. 早产儿肠道菌群与早期BMI轨迹的研究[J]. 实用预防医学, 2022, 29(7):844-848. [8] 吴宇佳, 迟晓培, 陈峰, 等. 肥胖者唾液微生物宏基因组学特点[J]. 北京大学学报(医学版), 2018, 50(1):5-12. [9] Deo PN, Deshmukh R. Oral microbiome: unveiling the fundamentals[J]. J Oral Maxillofac Pathol, 2019, 23(1):122-128. [10] Verma D,Garg PK,Dubey AK. Insights into the human oral microbiome[J]. Arch Microbiol, 2018, 200(4):525-540. [11] Jia G, Zhi A, Lai PFH, et al. The oral microbiota - a mechanistic role for systemic diseases[J]. Br Dent J, 2018, 224(6):447-455. [12] Tam J, Hoffmann T, Fischer S, et al. Obesity alters composition and diversity of the oral microbiota in patients with type 2 diabetes mellitus independently of glycemic control[J]. PLoS One, 2018, 13(10):e0204724. [13] Goodson JM, Groppo D, Halem S, et al. Is obesity an oral bacterial disease?[J]. J Dent Res, 2009, 88(6):519-523. [14] Stefura T, Zapaa B, Gosiewski T, et al. Differences in compositions of oral and fecal microbiota between patients with obesity and controls[J]. Medicina(Kaunas), 2021,57(7):678. [15] Craig SJC, Blankenberg D, Parodi ACL, et al. Child weight gain trajectories linked to oral microbiota composition[J]. Sci Rep, 2018, 8(1):14030. [16] Sohail MU, Elrayess MA, Al Thani AA, et al. Profiling the oral microbiome and plasma biochemistry of obese hyperglycemic subjects in Qatar[J]. Microorganisms, 2019, 7(12):645. [17] Alqaderi H, Ramakodi MP, Nizam R, et al. Salivary microbiome diversity in Kuwaiti adolescents with varied body mass index-a pilot study[J]. Microorganisms, 2021, 9(6):1222. [18] Besnard P, Christensen JE, Brignot H, et al. Obese subjects with specific gustatory papillae microbiota and salivary cues display an impairment to sense lipids[J]. Sci Rep, 2018, 8(1):6742. [19] Janem WF,Scannapieco FA,Sabharwal A,et al. Salivary inflammatory markers and microbiome in normoglycemic lean and obese children compared to obese children with type 2 diabetes[J]. PLoS One, 2017, 12(3):e0172647. [20] Hall MW,Singh N,Ng KF,et al. Inter-personal diversity and temporal dynamics of dental, tongue, and salivary microbiota in the healthy oral cavity[J]. NPJ Biofilms Microb, 2017, 3:2. [21] De Andrade DR,Silva PA,Colombo APV,et al. Subgingival microbiota in overweight and obese young adults with no destructive periodontal disease[J]. J Periodontol, 2021, 92(10):1410-1419. [22] Sasaki N,Katagiri S,Komazaki R,et al. Endotoxemia by porphyromonas gingivalis injection aggravates non-alcoholic fatty liver disease, disrupts glucose/lipid metabolism, and alters gut microbiota in mice[J]. Front Microbiol, 2018, 9:2470. [23] Yang Y, Cai Q, Zheng W, et al. Oral microbiome and obesity in a large study of low-income and African-American populations[J]. J Oral Microbiol, 2019, 11(1):1650597. [24] Rosing JA, Walker KC, Jensen BAH, et al. Oral lactobacillus counts predict weight gain susceptibility: a 6-year follow-up study[J]. Obes Facts, 2017, 10(5):473-482. [25] Asano M,Hong G,Matsuyama Y,et al. Association of oral fat sensitivity with body mass index, taste preference, and eating habits in healthy Japanese young adults[J]. Tohoku J Exp Med, 2016, 238(2):93-103. [26] Proserpio C, Laureati M, Bertoli S, et al. Determinants of obesity in Italian adults: the role of taste sensitivity, food liking, and food neophobia[J]. Chem Senses, 2016, 41(2):169-176. [27] Mameli C, Cattaneo C, Panelli S, et al. Taste perception and oral microbiota are associated with obesity in children and adolescents[J]. PLoS One, 2019, 14(9):e0221656. [28] Feng Y, Licandro H, Martin C, et al. The associations between biochemical and microbiological variables and taste differ in whole saliva and in the film lining the tongue[J]. Biomed Res Int, 2018, 2018: 2838052. [29] Takahashi N. Oral microbiome metabolism: from “who are they?” to “what are they doing?”[J]. J Dent Res, 2015, 94(12):1628-1637. [30] Nagpal R,Yamashiro Y,Izumi Y. The two-way association of periodontal infection with systemic disorders: an overview[J]. Mediators Inflamm, 2015, 2015:793898. [31] Le Sage F, Meilhac O, Gonthier MP. Porphyromonas gingivalis lipopolysaccharide induces pro-inflammatory adipokine secretion and oxidative stress by regulating toll-like receptor-mediated signaling pathways and redox enzymes in adipocytes[J]. Mol Cell Endocrinol, 2017, 446: 102-110. [32] Thomas C,Minty M,Canceill T,et al. Obesity drives an oral microbiota signature of female patients with periodontitis: a pilot study[J]. Diagnostics(Basel), 2021, 11(5):745. [33] Luche E,Cousin B,Garidou L, et al. Metabolic endotoxemia directly increases the proliferation of adipocyte precursors at the onset of metabolic diseases through a CD14-dependent mechanism[J]. Mol Metab, 2013, 2(3):281-291. [34] Wu Y, Chi X, Zhang Q, et al. Characterization of the salivary microbiome in people with obesity[J]. Peer J, 2018, 6:e4458. [35] Dong Z,Lv W,Zhang C,et al. Correlation analysis of gut microbiota and serum metabolome with Porphyromonas gingivalis-induced metabolic disorders[J]. Front Cell Infect Microbiol, 2022, 12:858902. [36] Kim DJ, Rho JH, Woo BH, et al. Periodontal pathogens modulate lipid flux via fatty acid binding protein 4[J]. J Dent Res, 2019, 98(13):1511-1520. [37] Moreno-Vedia J, Girona J, Ibarretxe D, et al. Unveiling the role of the fatty acid binding protein 4 in the metabolic-associated fatty liver disease[J]. Biomedicines, 2022, 10(1):197. [38] Frances L, Tavernier G, Viguerie N. Adipose-derived lipid-binding proteins: the good, the bad and the metabolic diseases[J]. Int J Mol Sci, 2021, 22(19):10460. [39] Ogawa A,Kobayashi T,Sakai F,et al. Lactobacillus gasseri SBT2055 suppresses fatty acid release through enlargement of fat emulsion size in vitro and promotes fecal fat excretion in healthy Japanese subjects[J]. Lipids Health Dis, 2015, 14:20. [40] Lu J,Zhang S,Huang Y,et al. Periodontitis-related salivary microbiota aggravates Alzheimer’s disease via gut-brain axis crosstalk[J]. Gut Microbes, 2022, 14(1):2126272. [41] Greenhill C. Childhood weight gain and oral microbiota[J]. Nat Rev Endocrinol, 2018, 14(12):689. [42] Arimatsu K, Yamada H, Miyazawa H, et al. Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota[J]. Sci Rep, 2014, 4:4828. [43] Kato T, Yamazaki K, Nakajima M, et al. Oral administration of porphyromonas gingivalis alters the gut microbiome and serum metabolome[J]. MSPHERE, 2018, 3(5):e00460. [44] Imai J, Kitamoto S, Kamada N. The pathogenic oral-gut-liver axis: new understandings and clinical implications[J]. Expert Rev Clin Immunol, 2021, 17(7):727-736. [45] Acharya C, Sahingur SE, Bajaj JS. Microbiota, cirrhosis, and the emerging oral-gut-liver axis[J]. JCI Insight, 2017, 2(19):e94416. [46] Nakajima M, Arimatsu K, Kato T, et al. Oral administration of P. gingivalis induces dysbiosis of gut microbiota and impaired barrier function leading to dissemination of enterobacteria to the liver[J]. PLoS One, 2015, 10(7):e0134234. [47] Kashiwagi Y,Aburaya S,Sugiyama N,et al. Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model[J]. Sci Rep, 2021, 11(1):18398. [48] Hatasa M, Ohsugi Y, Katagiri S, et al. Endotoxemia by porphyromonas gingivalisalters endocrine functions in brown adipose tissue[J]. Front Cell Infect Microbiol, 2020, 10:580577. [49] Alanzi A,Honkala S,Honkala E,et al. Effect of lactobacillus rhamnosus and bifidobacterium lactis on gingival health, dental plaque, and periodontopathogens in adolescents: a randomised placebo-controlled clinical trial[J]. Benef Microbes, 2018, 9(4):593-602. [50] Albuquerque-Souza E, Balzarini D, Ando-Suguimoto ES, et al. Probiotics alter the immune response of gingival epithelial cells challenged by porphyromonas gingivalis[J]. J Periodontal Res, 2019, 54(2):115-127. [51] Bueno MR,Ishikawa KH,Almeida-Santos G,et al. Lactobacilli attenuate the effect of aggregatibacter actinomycetemcomitans infection in gingival epithelial cells[J]. Front Microbiol, 2022, 13:846192. [52] Morita T, Yamazaki Y, Seto M, et al. Effect of periodontitis and toothbrushing frequency on obesity onset: a cohort study[J]. Med Sci Monit, 2019, 25:9712-9720.
2024, Vol. 31 
