Abstract：Objective To investigate the current situation of measles antibody level among natural population in Dongguan City so as to provide scientific evidence for formulating more scientific, feasible, effective and economical measures for measles prevention and control. Methods Based on the regional distribution characteristics of Dongguan, 5 towns/streets and 15 neighborhood committees/administrative villages were selected from different areas using the multi-stage random sampling method. 4 persons were randomly recruited from each month-age group of the infants aged 0-12 months, each year-age group of children aged 1-14 years and each group of 15-, 20-, 25-, 30-, 35-, 40- and 45 years old in each neighborhood committee/administrative village. In order to ensure enough women of childbearing age recruited, the ratio of male to female subjects in each group aged ≥ 15 years was 11. Finally, 2,043 individuals were recruited for monitoring. Venous blood was collected from each subject and serum was separated. Enzyme linked immunosorbent assay (ELISA) was used to detect serum measles IgG antibody. Results The measles antibody levels in the population with household registry of other cities in Guangdong Province (geometric mean concentration (GMC) 1,092.38 mIU/ml, positive rate 81.53% and protection rate 53.13%) and in the population with household registry of other provinces (GMC 985.80 mIU/ml, positive rate 73.12% and protection rate 48.29%) were lower than those of the population with household registry of Dongguan City (GMC 1,106.79 mIU/ml, positive rate 85.09% and protection rate 54.83%), of which the positive rate(χ2=35.789, P<0.001) and protection rate were statistically different (χ2=6.606, P=0.037). The measles antibody levels were significantly among various age groups (FGMC=26.388, P<0.001; χ2positive rate=905.853, P<0.001; χ2protection rate=436.861, P<0.001).The measles antibody levels of the infants aged 2-8 months (GMC 257.74-613.53 mIU/ml, positive rate 10.53%-62.40% and protection rate 4.39%-23.20%) were the lowest, and those of children aged 9-15 years (GMC 879.12-987.97 mIU/ml, positive rate 89.57%-92.62% and protection rate 40.68%-54.78%) were also lower. The measles antibody GMC fluctuated around 1,200 mIU/ml in women of childbearing age of 15-35 years old, but significantly increased in women of childbearing age of 35- years old. The changing trend of antibody positive rate and protection rate were roughly similar to that of antibody GMC. Conclusions In Dongguan City in 2013, the residents with household registry of cities other than Dongguan in Guangdong Province, infants aged 2-8 months, children aged 9-15 years and women of childbearing age younger than 35 years old are the populations with lower levels of measles antibody. To strengthen immune interventions, such as routine immunization, health propaganda and education, supplementary immunization and emergency vaccination is conducive to realizing the effective prevention and control of measles in low epidemic.
唐萃菲, 陈绍丽, 张巧利, 莫想换, 林瑞彬, 王莹. 2013年东莞市自然人群麻疹抗体水平监测分析[J]. 实用预防医学, 2016, 23(12): 1444-1447.
TANG Cui-fei, CHEN Shao-li, ZHANG Qiao-li, MO Xiang-huan, LIN Rui-bin, WANG Ying. Surveillance on the antibody level of measles in natural population in Dongguan City, 2013. , 2016, 23(12): 1444-1447.
2016, Vol. 23 
