摘要目的 调查研究扬州地区15～49岁育龄期女性乙型肝炎和丙型肝炎血清标志物流行率,为病毒性肝炎防治工作提供理论依据。方法 收集2019年1月—2021年12月在扬州某综合性三甲医院行乙肝表面抗原(hepatitis B surface antigen, HBsAg)、乙肝表面抗体(hepatitis B surface antibody, HBsAb)、乙肝e抗原(hepatitis B e antibody, HBeAg)和丙肝抗体(anti-hepatitis C virus, anti-HCV)检查的58 429例育龄期女性的临床资料和血清学检查结果,分析血清流行率。结果 就诊于该医院的育龄期女性HBsAg阳性率为6.15%,阳性率在2019—2021年间呈下降趋势(χ2趋势=16.973,P<0.001),阳性率随年龄增长呈上升趋势(χ2趋势=595.607,P<0.001),随着国家免疫计划的不断深入,HBsAg阳性率随受检者出生年份增长逐年下降(χ2趋势=645.222,P<0.001)。就诊于该医院的育龄期女性HBsAb阳性率为49.99%,HBsAg阳性的育龄期女性中HBeAg阳性检出率为17.36%。anti-HCV阳性率为0.34%,阳性率随年龄增长呈上升趋势(χ2趋势=29.257,P<0.001)。结论 通过就诊该医院的育龄期女性检测结果反映出扬州地区育龄期女性HBsAg阳性率虽呈逐年下降趋势,但仍偏高;anti-HCV阳性率维持在相对较低水平;年龄是影响因素,应重点加强35岁以下育龄期女性病毒性肝炎的筛查和疫苗接种工作。
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2023, Vol. 30 
