Abstract:Objective To investigate the epidemiological features of viral hepatitis B and C in Shenzhen City from 2010 to 2014, and to put forward evidence for viral hepatitis prevention and treatment in the local areas. Methods The data regarding viral hepatitis B and C network reported cases in Shenzhen City during 2010-2014 were collected from China Disease Prevention and Control Information System and statistically analyzed. Two physical examination clinics in the local areas were randomly selected to investigate the status of hepatitis C virus infection. Results A total of 3,497 hepatitis B cases were cumulatively reported in Shenzhen City during 2010-2014, with the reported incidence rate and the average incidence rate being 6.31/100,000-10.21/100,000 and 7.58/100,000 respectively. A total of 613 hepatitis C cases were cumulatively reported, with the reported incidence rate and the average incidence rate being 1.11/100,000-1.68/100,000 and 1.33/100,000 respectively. The male to female ratios for hepatitis B and C cases were 11.45:1 and 2.70:1 respectively. The proportions of chronic hepatitis C and B cases were 59.87% (367/613) and 95.08% (3,325/3,497) respectively. The proportions of hepatitis B and C cases in the local registered population were 81.73%(2,858/3,497)and 89.07%(546/613)respectively. The proportions of cumulatively reported cases of hepatitis B and C in the residents aged 25-44 years during the 5-year period were 58.39%(2,042/3,497)and 55.63%(341/613) respectively. Six patients infected with HCV were detected in the physical examination clinics from January to December, 2014, with the infection rate of 0.30% (6/1,983). Conclusions The overall annual incidence rates of hepatitis B and C in Shenzhen City during 2010-2014 show a declining trend. The male cases are more than the female ones, and most of the cases are the young and middle-aged local residents with chronic hepatitis B or C. The rates of hepatitis C infection in the physical examination clinics are significantly higher than the average annual reported levels over the years. We should standardize the network reporting work of local infectious diseases, expand the coverage of hepatitis B and C detection, establish files for hepatitis C patients diagnosed in the physical examination clinics and transfer them to medical institutions, and bring hepatitis B and C prevention and control work into the community public health service system.