HCV-RNA viral load and its related factors among anti-HCV positive attendants in a methadone maintenance treatment clinic in Guangxi
LI Rong-jian1, PAN Ling2, SHI Shan3, WEI Li-kui3, LAN Guang-hua1, PANG Lin2
1. Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning, Guangxi 530028, China; 2. National Center for AIDS/STD Control and Prevention, China CDC, Beijing 102206, China; 3. Red Cross Hospital of Nanning City, Nanning, Guangxi 530012, China
Abstract：Objective To detect the HCV-RNA viral load among anti-HCV positive attendants in a methadone maintenance treatment (MMT) clinic in Guangxi, and to explore its associated influencing factors. Methods We surveyed anti-HCV positive attendants in a methadone maintenance treatment (MMT) clinic in Guangxi Province. Their information about general demography, drug addiction and HIV infection status was collected, and laboratory tests including HCV-RNA viral load, blood routine and liver function were conducted. Results A total of 257 anti-HCV positive attendants received the above-mentioned laboratory tests. Among them, 209 (81.32%) were HCV-RNA-positive, 48 (18.68%) were HIV positive, and 139 (54.09%)had anAST/ALT ratio above 1. Along with the growth of HCV-RNA viral load, the rates of abnormal AST value, abnormal ALT value and HCV/HIV co-infection all increased (Chi-square test for trend test, all P<0.05). Conclusions Most of the anti-HCV positive attendants in the MMT clinic are patients with chronic hepatitis C virus infection, and some of them have already developed into liver fibrosis or cirrhosis. In addition, the viral load is correlated with abnormal AST value, abnormal ALT value, and HIV/HCV co-infection. It is suggested that more attention should be paid to HCV prevention and treatment so as to contain further spread of HCV.
李荣健, 潘玲, 石珊, 韦利葵, 蓝光华, 庞琳. 广西某美沙酮维持治疗门诊HCV抗体阳性就诊者病毒载量及相关因素分析[J]. 实用预防医学, 2021, 28(1): 29-31.
LI Rong-jian, PAN Ling, SHI Shan, WEI Li-kui, LAN Guang-hua, PANG Lin. HCV-RNA viral load and its related factors among anti-HCV positive attendants in a methadone maintenance treatment clinic in Guangxi. , 2021, 28(1): 29-31.
2021, Vol. 28 
