Medication adherence and its influencing factors among patients undergoing methadone maintenance treatment in Dongcheng District of Beijing, 2006-2020
TIAN Fei1, LIU Guo-wu2, MA Wen-li3, ZHANG Jian-ping4
1. Dongcheng District Center for Disease Control and Prevention, Beijing 100050, China; 2. Beijing Center for Disease Control and Prevention, Beijing 100013, China; 3. The First People's Hospital of Dongcheng District, Beijing 100077, China; 4. Mental Health Care Institute of Dongcheng District, Beijing 100027, China
Abstract：Objective To understand the compliance and affecting factors of patients in methadone maintenance treatment (MMT) clinics in Dongcheng District, Beijing, and to provide a scientific basis for establishment of reasonable treatment mode and intervention measures in clinical practice. Methods A dynamic cohort study design was adopted. The starting point of the study was the time of the first treatment of patients in MMT clinics, and the end point was April 30, 2021. Service life table analysis was performed to evaluate the maintenance treatment. COX proportional hazard model was used to analyze the factors influencing the patients' compliance. Results A total of 331 patients were enrolled in this study. Up to the end point of follow-up, 210 (63.44%) cases had recurrent loss. The median duration of the maintenance treatment was 5.33 years. The cumulative proportions of 1-year, 2- and 5-years maintenance treatment in the patients were 77.05%, 67.67% and 52.41%, respectively. The 1-year, 2- and 5-years maintenance treatment was 279.00, 234.50 and 170.00 person-years, respectively. COX proportional hazard model analysisshowed that age at enrollment <50 years old (HR=1.825, 95%CI:1.087-3.062), being employed (HR=1.515, 95%CI:1.037-2.213), daily dose <60 mg/d (HR=2.025, 95%CI:1.380-2.972) and receiving compulsory isolationdetoxification (HR=2.617, 95%CI:1.345-5.092) were risk factors for reducing the patients' compliance. Conclusion Daily dose, occupation, age at the time of enrollment, and whether or not receiving compulsory isolation detoxification were factors influencing compliance of MMT outpatients in Dongcheng District, Beijing. The reduction of daily dose may lead to decrease of the patients' compliance and ultimately affects the treatment effect, so doctors in clinics should be cautious about reducing the patients' dose.
田飞, 刘国武, 马文立, 张建萍. 2006—2020年北京市东城区美沙酮维持治疗患者依从性及影响因素分析[J]. 实用预防医学, 2022, 29(5): 532-535.
TIAN Fei, LIU Guo-wu, MA Wen-li, ZHANG Jian-ping. Medication adherence and its influencing factors among patients undergoing methadone maintenance treatment in Dongcheng District of Beijing, 2006-2020. , 2022, 29(5): 532-535.
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2022, Vol. 29 
