Abstract：Objective To understand the drug resistance of bacteria in the Liangshan Yi Area, and to provide a basis for rational use of antibiotics in clinical practice. Methods We collected clinically isolated pathogens in the First People's Hospital of Liangshan Yi Autonomous Prefecture from January 1, 2018 to December 31, 2020. Automatic microorganism identification and drug sensitivity determination system was used to identify the pathogens and perform drug sensitivity test. All the experimental data were analyzed by WHONET 5.6 software. Results A total of 8,479 strains of pathogenic bacteria were isolated from the hospital in 2018-2020, of which gram-negative bacteria accounted for 64.97% (5,509/8,479) and gram-positive bacteria for 35.03% (2,970/8,479). Most of the gram-positive bacteria isolated were Staphylococcus aureus (974/2,970). They showed high sensitivity to nitrofurantoin, linezolid, vancomycin and daptomycin, but high resistance to penicillin and ampicillin. At the same time 336 strains of methicillin-resistant Staphylococcus aureus (MRSA) were detected. Most of the gram-negative bacteria detected were Escherichia coli (1,894/5,509). Their resistance to cefazolin, cefepime, ceftriaxone, cefotaxime and ceftazidime was all more than 60%, but they were sensitive to tigecycline, with the resistance being only 0.16%. They were resistant to imipenem, meropenem and ertapenem in different degrees. 1,071 strains of Escherichia coli producing extended spectrum beta-lactamases (ESBLs) (57.92%, 1,071/1,894) and 272 strains of Klebsiella pneumoniae (32.27%, 272/843) were detected. Conclusion There were some changes in the clinical drug-resistant bacteria detected in this hospital during2018-2020 compared with the surveillance data of drug-resistant bacteria during 2015-2017, but the drug resistance was still very serious. We should use antimicrobial agents rationally, strengthen the monitoring of bacterial drug resistance, and strictlyimplement isolation and disinfection measures.
陈旭, 王琳, 李享宸, 陈丽, 周文, 李俊如, 李键, 黄静, 古荣. 2018—2020年凉山彝族地区某医院细菌耐药性监测分析[J]. 实用预防医学, 2022, 29(12): 1443-1447.
CHEN Xu, WANG Lin, LI Xiang-chen, CHEN Li, ZHOU Wen, LI Jun-ru, LI Jian, HUANG Jing, GU Rong. Monitoring of bacterial drug resistance in a hospital in the Liangshan Yi Area, 2018-2020. , 2022, 29(12): 1443-1447.
2022, Vol. 29 
