Clinical characteristics and etiological analysis of Yersinia enterocolitica infection in children under 5 years old in China
WU Wei-wei1,4, LU Xin-min2, YU Quan-xi3, DUAN Ran1, QIN Shuai1, JING Huai-qi1, WANG Xin1
1. National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; 2. Aksai Kazakh Autonomous County Center for Disease Control and Prevention, Jiuquan, Gansu 735000, China; 3. Subei Mongolian Autonomous County Center for Disease Control and Prevention, Jiuquan, Gansu 735000, China; 4. Xuzhou Municipal Center for Disease Control and Prevention, Xuzhou, Jiangsu 221000, China
Abstract：Objective To understand the clinical and etiological characteristics of Yersinia enterocolitica diarrhea in children under 5 years old in China, to analyze the possible source of infection, and to provide a scientific basis for prevention, control and diagnosis of Yersinia enterocolitica infection. Methods We collected children’s diarrhea specimens, survey and follow-up questionnaires from sentinel hospitals across 10 provinces and cities from 2010 to 2020. Yersinia enterocolitica was isolated from the specimens, and biotypes and serotypes of the strains were identified. Virulence genes detection and pulsed field gel electrophoresis (PFGE) were conducted. Results A total of 11,377 cases were monitored from 2010 to 2020, and 63 strains of pathogenic Yersinia enterocolitica were isolated, including 61 strains of O:3 serotype and 2 strains of O:9 serotype. The infection rate of diarrhea children under 5 years old was 0.55% (63/11,377). No statistically significant difference was found in the infection rate of Yersinia enterocolitica between boys and girls, but the infection rate was higher in children aged 1-5 years than in ones aged ≤1 years (χ2=44.836, P<0.05). In diarrhea children with pathogenic Yersinia enterocolitica, the fever ratio was higher in children aged 1-5 years than in ones aged ≤ 1 years (χ2=11.508, P<0.05). No complications were observed in the follow-up cases. The PFGE patterns of O:3 serotype strains in children with pathogenic Yersinia enterocolitica were diverse, and the main dominant patterns were K6GN11C30021 and K6GN11C30012. Conclusion The bio-serotype of pathogenic Yersinia enterocolitica in children under 5 years old in China are mainly 3/O:3, but occasionally 4/O:3 and 2/O:9. According to the children's infection characteristics and the peak season, it is speculated that food is the main source of infection, which needs further investigation.
吴畏畏, 鲁新民, 俞全喜, 段然, 秦帅, 景怀琦, 王鑫. 我国5岁以下儿童小肠结肠炎耶尔森菌感染临床特征及病原学分析[J]. 实用预防医学, 2022, 29(3): 257-260.
WU Wei-wei, LU Xin-min, YU Quan-xi, DUAN Ran, QIN Shuai, JING Huai-qi, WANG Xin. Clinical characteristics and etiological analysis of Yersinia enterocolitica infection in children under 5 years old in China. , 2022, 29(3): 257-260.
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