Evaluation on the effect of emergency inoculation and other prevention and control measures during an outbreak of epidemic mumps
ZHANG Min1, CHEN Tian-mu2, YE Wei-guo1, CHEN Yi-xiong3, NI Ping4
1.Shiyan Health Inspection Institute of Bao’an District of Shenzhen City, Shenzhen, Guangdong 518108, China; 2. Changsha Center for Disease Control and Prevention, Changsha, Hunan 410000, China;
3. Bao’an District Center for Disease Control and Prevention, Shenzhen, Guangdong 518100, China;
4. Ganzi Prefecture Center for Disease Control and Prevention, Ganzi, Sichuan 626000, China
Abstract：Objective To evaluate the efficacy of emergency inoculation and other prevention and control measures during an outbreak of epidemic mumps. Methods According to the case definition, we collected the data of all cases in this outbreak, including illness onset date, case isolation date, returning to school date, emergency vaccination date and times, school closure date and interval and health education like hand-washing. The vaccine efficacy (VE) of emergency vaccination was calculated. A discrete-time model was employed to simulate the transmissibility and effectiveness of the measures, including the proportion of isolation and effectiveness indexes of emergency vaccination, case isolation, school closure and hand-washing.Results A total of 1,471 students were surveyed in this outbreak. The outbreak experienced 4 generations of cases, with an average interval of 15 days. Altogether 339 students received measles-mumps-rubella vaccine during the outbreak, and the emergency inoculation rate was 73.38%. 3 students were infected with mumps, with the attack rate of 0.88%. 123 students did not receive the emergency inoculation, 25 students were infected with mumps, with the attack rate of 20.33%. The VE of the emergency inoculation was 95.6%. The effectiveness indexes of isolation in the 2rd-4th generations of cases were 0.43, 0.46 and 0.47 respectively. School closure and hand-washing became effective in the 2nd-3rd generations of cases, with the effectiveness indexes of 0.279 and 0.078 respectively. According to the simulation results of the model, there would become effective in total attack rate, duration of outbreak and epidemic peak week while the emergency inoculation rate was up to 90%-100%. Conclusions There will not be obvious effect in mumps outbreak unless the emergency inoculation rate runs up to 90%-100%. Health education like school closure and hand-washing can make some effects, but a high vaccination rate and timely isolation of cases should be considered as the primary prevention and control measures.
张敏,陈田木,叶伟国,陈亿雄,倪萍. 应急接种等措施在一起流行性腮腺炎暴发疫情防控中的效果评价[J]. 实用预防医学, 2019, 26(7): 832-835.
ZHANG Min, CHEN Tian-mu, YE Wei-guo, CHEN Yi-xiong, NI Ping. Evaluation on the effect of emergency inoculation and other prevention and control measures during an outbreak of epidemic mumps. , 2019, 26(7): 832-835.
2019, Vol. 26 
