Abstract：Objective To study the relationship between neutropenia and opportunistic infection in severe-stage AIDS patients before and after receiving highly active antiretroviral therapy (HAART). Methods We retrospectively analyzed 138 patients diagnosed with severe-stage AIDS. All the patients’ opportunistic infections were controlled and entered the secondary prevention and HAART stage. According to the blood routine test of pre-HAART baseline, the patients were divided into the low neutrophil group (neutrophil absolute count ≤ 2×109/L, n=77) and the normal group (neutrophil absolute count ＞2×109/L, n=61). Six months after receiving HAART, we compared the reinfection rate and average days of antibiotic use between the two groups, and analyzed the correlation of baseline neutrophil count with days of antibiotic use and reinfection. Results Observation continued for a 6-month period. The reinfection rate in the low neutrophil group and the normal group was 59.7% and 34.4% respectively, and the difference was statistically significant (χ2=8.732, P<0.05). The patients’ baseline neutrophil count was negatively correlated with their reinfection frequency (rs=-0.31, P<0.05) and days of antibiotic use (rs=-0.299, P<0.05). Conclusions In the early stage of HAART, severe-stage AIDS complicated with neutropenia can increase the patients’ risk of reinfection. It is therefore of great clinical significance to monitor the level of neutrophils in the patients and timely detect and treat their reinfections.
陆鹏, 莫让辉, 梁柱石. 艾滋病严重疾病期合并中性粒细胞减少症与再感染的关系[J]. 实用预防医学, 2019, 26(6): 703-706.
LU Peng, MO Rang-hui, LIANG Zhu-shi. Relationship between severe-stage AIDS complicated with neutropenia and reinfection. , 2019, 26(6): 703-706.
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