维吾尔族人群<i>PNPLA3</i>-rs738409多态性和吸烟交互作用与非酒精性脂肪肝的关联研究

doi:10.3969/j.issn.1006-3110.2018.05.002

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摘要目的探讨维吾尔族PNPLA3 rs738409多态性与非酒精性脂肪肝遗传易感性相关性。方法对维吾尔族非酒精脂肪肝(NAFLD)患者203名,维吾尔族健康体检者188名(对照组)进行包括肝脏B超检测、血液生化指标检测,同时采用Snapshot技术检测PNPLA3 rs738409基因分型,采用SPSS 16.0统计软件分析数据。结果维吾尔族PNPLA3 rs738409 G等位基因频率分布,在NAFLD组是41.63％,对照组是31.12％;NAFLD组与对照组G等位基因频率分布差异有统计学意义(χ²=6.013,P=0.014)。多元logistic回归分析显示,相对于CC基因型,GG基因型发生NAFLD的OR大于2.0(OR=4.290,95%CI:1.619~11.370,P=0.003);PNPLA3-rs738409GG基因型与吸烟存在交互作用(P=0.017)。结论 PNPLA3-rs738409多态性与维吾尔族人群NAFLD的易感性显著关联,且与吸烟有交互作用。

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	蔡雯
	翁迪华
	林素兰
	王淑霞
	买拉木古丽
	姚华

关键词 ：非酒精性脂肪肝, 基因多态性, 吸烟, 交互作用

Abstract：Objective To explore the correlation between the polymorphism of patatin-like phospholipase domain containing 3 (PNPLA3) gene (rs738409) and hereditary susceptibility to nonalcoholic fatty liver disease (NAFLD) in Uyhgur population. Methods Liver B-ultrasound and blood biochemical indexes were detected in 203 Uyhgur patients with NAFLD and 188 Uyhgur health examinees (serving as the control group). The PNPLA3 genotype at rs738409 was determined by using Snapshot assay. And SPSS 16.0 software was used to analyze the data. Results There were statistically significant differences in the frequency distribution of G allele genotype between the NAFLD group and the control group (41.63% vs. 31.12%, χ²=6.013, P=0.014). Multivariate logistic regression analysis showed that the odds ratio (OR) value was greater than 2.0 in the risk of developing NAFLD from the carriers of the PNPLA3-rs738409 GG genotype than those of the PNPLA3-rs738409 CC genotype (OR=4.290, 95%CI:1.619-11.370, P=0.003). There was an interaction between the PNPLA3-rs738409GG genetype and active smoking. Conclusions PNPLA3-rs738409 polymorphism is significantly associated with the susceptibility to developing NAFLD in Uyhgur population; moreover, it interacts with smoking.

Key words： nonalcoholic fatty liver disease polymorphism smoking interaction　　　

收稿日期: 2017-03-03

R575.5

基金资助:国家自然科学基金(81460120)

通讯作者: 姚华,E-mail:2276823028@qq.com。

作者简介: 蔡雯(1982-),女,江苏沛县人,博士,副教授,研究方向:环境-疾病-基因。

引用本文:

蔡雯, 翁迪华, 林素兰, 王淑霞, 买拉木古丽, 姚华. 维吾尔族人群PNPLA3-rs738409多态性和吸烟交互作用与非酒精性脂肪肝的关联研究[J]. 实用预防医学, 2018, 25(5): 517-519. CAI Wen, WENG Di-hua, LIN Su-lan, WANG Shu-xia, MAI Lamuguli, YAO Hua. Association between nonalcoholic fatty liver disease and interaction of PNPLA3-rs738409 polymorphism and smoking in Uyghur population. , 2018, 25(5): 517-519.

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https://www.syyfyx.com/CN/10.3969/j.issn.1006-3110.2018.05.002 或 https://www.syyfyx.com/CN/Y2018/V25/I5/517

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