Abstract：Objective To investigate the germ-carrying rate of epidemic cerebrospinal meningitis and the changes of bacteria type distribution among healthy population in Handan City, and to provide a basis for forecasting the tendency of incidence of epidemic cerebrospinal meningitis and rationally formulating its prevention and control measures. Methods The throat swab specimens were collected from 7 age groups of healthy population during 2009-2015, and then inoculated in chocolate double anti-AGAR plate to isolate, cultivate and identify Neisseria meningitidis (N. meningitidis). Results A total of 3,528 throat swab specimens were collected from healthy population, and 100 positive strains were detected, with the germ-carrying rate being 2.83%. 71 strains were identified by serum grouping, of which 8 strains were characterized in serogroup A, 36 strains in serogroup B, 18 strains in serogroup C and 9 strains in serogroup W135. 29 strains were unidentified, including 12 strains of multiple-coagulate bacteria, 8 strains of self-coagulate bacteria and 9 strains of non-coagulate bacteria, and the germ-carrying rate of the age group of 15- years was the highest. The unidentified strains were typed molecularly by PCR, and 18 strains were identified (with the typing rate being 62.1%), including 3 strains in serogroup A, 8 strains in serogroup B, 6 strains in serogroup C, 1 strain in serogroup 29E. But 11 strains still remained unidentified. Conclusions The germ-carrying rate of epidemic cerebrospinal meningitisamong the healthy population in Handan City from 2009 to 2015 was low,but the carrying rates in the age groups of 10-, 15- and 25- years were slightly higher. Serogroup B N. meningitidis strains prevailed and mainly prevailed in the age groups of 10-15 yearsduring the period of 2009-2011, and were supplanted by serogroup C and serogroup W135 N. meningitidis strains in 2014-2015. Therefore, more attention should be paid to intensifying health propaganda and expanding the coverage rate of meningococcal meningitis vaccine.
闫永飞, 赵丽萍, 郭娜娜, 马艳霞, 李燕霞, 李瑞芳, 邓健, 黄亮. 2009-2015年邯郸市健康人群流行性脑脊髓膜炎带菌率调查及分子分型研究[J]. 实用预防医学, 2018, 25(2): 209-211.
YAN Yong-fei, ZHAO Li-ping, GUO Na-na, MA Yan-xia, LI Yan-xia, LI Rui-fang, DENG Jian, HUANG Liang. Germ-carrying rate of epidemic cerebrospinal meningitis and molecular typing of bacteria among healthy population in Handan City, 2009-2015. , 2018, 25(2): 209-211.
2018, Vol. 25 
