Abstract:Objective To analyze the characteristics of temporal and spatial distribution of reported syphilis cases in Hunan Province from 2010 to 2020, and to provide a scientific basis for determining the key prevention and control areas and formulating targeted prevention and treatment strategies. Methods We collected the reported incidence of syphilis in Hunan Province during 2010-2020. ArcGIS 10.8 software was used for spatial autocorrelation analysis, and SaTScan 9.7 software for spatio-temporal scanning analysis. Results The reported incidence rates of syphilis in Hunan Province during 2010-2020 showed an increasing trend, with an average annual growth rate of 6.27%. Results from global spatial autocorrelation analysis revealed that the reported incidence rates of syphilis in Hunan Province during 2010-2020 showed positive spatial autocorrelation (Moran's I=0.2454-0.4217, P<0.001). Results from the Getis-Ord General G spatial autocorrelation analysis displayed that the hot spots wereconcentrated in Changsha-Zhuzhou-Xiangtan urban agglomeration and the western region centered on Huaihua, while the cold spots were the southern region centered on Hengyang. Results from the phased spatio-temporal scanning analysis identified four cluster areas from 2010 to 2020, seven cluster areas in 2010-2015 and six cluster areas between 2016 and 2020. Conclusion The reported incidence rates of syphilis in Hunan Province during 2010-2020 presented an upward trend with obvious spatial clustering. Numbers of cluster areas through the phased spatio-temporal scanning analysis gradually decreased. The syphilis control program has achieved some success, and it is still necessary to continue to pay attention to the key areas with reported syphilis cases