Abstract:Objective To explore the etiology and transmission routes of COVID-19 through investigating and analyzing the epidemiology of a COVID-19 cluster, and to provide a basis for formulating epidemic prevention and control strategies and measures. Methods Descriptive epidemiological analysis was conducted on epidemiological investigation data, laboratory test results and epidemic response of a COVID-19 cluster in Luzhou City. Results There were 9 confirmed COVID-19 cases reported in this cluster epidemic, including 6 males and 3 females, and they were mainly relatives of a large family. The average age was 39 years. The oldest was 68 years old, while the youngest was 5 years old. Most of the cases were farmers (n=6, 66.7%). The unemployed and students accounted for 22.2% (n=2), and worker for 11.1% (n=1). The main clinical manifestations were fever, dry cough and runny nose. 5 cases had fever (55.6%), 5 cases had cough (55.6%),mainly dry cough,and 4 cases had a runny nose (44%). There were 1 critically-ill case, 2 severe cases and 6 mild cases. Cases Ⅰ and Ⅱ were indicative cases, and they were all returned to Luzhou by the same vehicle from Wuhan. Among them, the case Ⅱ caused cases Ⅲ-Ⅶ with the exception of case Ⅰ. Cases Ⅷ and Ⅸ were the third-generation cases caused by case Ⅶ. Conclusions This epidemic was a cluster epidemic caused by family members or relatives and friends. Early detection and standardized isolation and treatment of infectious sources, strengthening publicity, improving public awareness of epidemic prevention and control, and reducing the population aggregation are important measures to control the cluster epidemic.