维生素B<sub>2</sub>对儿童偏头痛防治有效性的meta分析

doi:10.3969/j.issn.1006-3110.2020.09.014

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摘要目的评价维生素B₂对儿童偏头痛发作频率和缓解疼痛程度的有效性。方法检索 PubMed、 EMbase、the Cochrane Library、CNKI、维普、万方数据库,截至2018年4月30日的所有有关维生素B₂对儿童偏头痛预防和治疗作用的随机对照试验。依据纳入和排除标准筛选文献,提取资料并进行方法学质量评估。采用 RevMan 5.3软件进行meta分析。结果共纳入6组随机对照试验。meta分析结果表明:治疗组偏头痛发病率低于对照组(安慰剂),差异有统计学意义(MD=-1.97,95%CI:-3.72~-0.23,P=0.03),治疗组偏头痛疼痛指数与对照组差异无统计学意义(SMD=-0.53,95%Cl:-1.37~0.30,P=0.21),剔除方法学质量评分较低的研究,敏感性分析的结果不变。亚组分析显示低剂量(50 mg)可能是影响异质升高的原因。结论现有试验证据表明,维生素B₂可以降低儿童偏头痛发生频率,但对减轻偏头痛疼痛指数无明显影响。

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	蔡响
	刘桃成
	吕媛
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	查文婷

关键词 ：维生素B₂, 儿童偏头痛, meta分析

Abstract：Objective To evaluate the effectiveness of vitamin B₂ on reducing the frequency of migraine attack and pain relief in children. Methods PubMed, EMbase, the Cochrane Library, CNKI, VIP and Wanfang database were searched for allrandomized-controlled trials of vitamin B₂ in the prevention and treatment of migraine in children as of April 30, 2018. Theliteratures were screened according to inclusion and exclusion criteria, the data were extracted and the methodological quality was assessed. RevMan 5.3 was used for meta analysis. Results A total of 6 groups of randomized-controlled trials were included. The results of meta analysis showed that the incidence of migraine in the treatment group was lower than that in the control group (placebo), with a statistically significant difference (MD=-1.97, 95%CI:-3.72-0.23, P=0.03). No statistically significant difference was found in migraine pain index between the treatment group and the control group (SMD=-0.53, 95%Cl:-1.37-0.30, P=0.21). The results of sensitivity analysis remained unchanged after excluding trails with lower methodological quality scores. Subgroup analysis showed that low dose (50 mg) might be the cause of heterogeneous elevation. Conclusions The existing experimental evidence shows that vitamin B₂ can reduce the frequency of migraine attack in children, but has no significant effect on reducing migraine pain index.

Key words： vitamin B₂ childhood migraine meta analysis

收稿日期: 2019-09-29

R591.42

引用本文:

蔡响, 刘桃成, 吕媛, 易尚辉, 查文婷. 维生素B₂对儿童偏头痛防治有效性的meta分析[J]. 实用预防医学, 2020, 27(9): 1077-1080. CAI Xiang, LIU Tao-cheng, LYU Yuan, YI Shang-hui, ZHA Wen-ting. Efficacy of vitamin B₂ in prevention and treatment of migraine in children: a meta-analysis. , 2020, 27(9): 1077-1080.

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