1. Chengdu Municipal Center for Disease Control and Prevention, Chengdu, Sichuan 610041, China; 2. Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China
Abstract：Objective To analyze the composition of viral genotypes in aggregation epidemics induced by norovirus infection in Chengdu region in 2017-2018, and to provide a basis for its prevention and control. Methods Anal swab samples from aggregation epidemics induced by norovirus infection in Chengdu region during 2017-2018 were selected, and then the sequence information of RdRp and VP1 was analyzed. The phylogenetic tree was constructed to analyze the nucleotide sequence homology. Results The sequence analysis revealed that 16.2% (11/68) samples belonged to NoV genogroup GI (including GI.2, GI.3 and GI.5). 83.8% (57/68) samples belonged to NoV genogroup GII (including GII.P16-GII.2, GII.P17-GII.17, GII.P8-GII.8, GII.P12-GII.3, GII.P7-GII.6 and GII.P15-GII.15). GII.P16-GII.2 was the main genotype circulating in 2017. Genogroups GI and GII.P17-GII.17 significantly prevailed in 2018; meanwhile, other four genotypes were detected. The variation of noroviruses with different genotypes was not obvious. The nucleotide sequence homology ranged from 93.4% to 100%. Conclusions The genotype composition of norovirus strains predominated in Chengdu region in 2018 was more complicated than that in 2017, which might be related to the increase of aggregation epidemics. It is necessary to continuously monitor the molecular epidemiology of norovirus strains and master the variation of norovirus in time so as to improve the early warning ability in disease prevention and control.
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2020, Vol. 27 
