Abstract:Objective To study the relationship between routine blood test and CD4+、CD8+ cell count,and look for simple、cheap、 efficient and stable AIDS progression monitoring indicator.[Methods] 282 person-time blood tests were collected. The methods of regression analysis were applied to research the relationship between WBC、W-SCC、W-LCC、RBC、HGB、PLT and CD4+、CD8+ cell count among HIV/AIDS.[Results]The rate of routine blood abnormalities among HIV/AIDS was very high, the main test indexes within the reference range were only 32.98%.Significant correlations with CD4+ cell count were observed for WBC, W - SCC, W - LCC, RBC, HGB and PLT. The correlation coefficient were 0.359, 0.499, 0.138, 0.172, 0.121, 0.150. The equation between W - SCC (x) and CD4 + cell count (y): y = 101.32 + 122.02 x.[Conclusion] The relationship between W-SCC and CD4+ cell count was significant. It was an important indicator of disease development stage among HIV/AIDS.
基金资助:江苏省昆山市社会发展科技计划项目(KS1353)
作者简介: 薛黎坚,男,1982—,硕士,主管医师,研究方向为性病艾滋病防制及公共卫生管理。
引用本文:
薛黎坚,王文明,陈权,姚庆完,田昌伟,王华. 淋巴细胞计数预测HIV/AIDS患者CD4+细胞的相关研究[J]. 实用预防医学, 2015, 22(12): 1437-1440.
XUE Li-jian, WANG Wen-ming, CHEN Quan, YAO Qing-wan, TIAN Chang-wei, WANG Hua.. The correlation between Lymphocyte count and CD4 + cell count among HIV/AIDS patients.. , 2015, 22(12): 1437-1440.
[1] Tansuphasawadikul S,Amornkul PN,Tanchanpong C,et a1.Clinical presentation of hospitalized adult patients with HIV infection and AIDS in Bangkok,Thailand[J]. J Acquir Immune Defic Syndr,1999,21(4):326-332. [2] 熊立凡,李树仁.临床检验基础[M].第3版.北京:人民卫生出版社,2006:24. [3] 李在村,吴昊.HIV/AIDS患者贫血的研究进展 [J].国外医学流行病学传染病学分册,2004,31(6):351-353. [4] 丁红.人类免疫缺陷病毒感染者全血常规结果的临床分析[J].国际检验医学杂志,2011,32(14):1630-1631. [5] 李在村,董培玲,张可,等.325例艾滋病患者和人类免疫缺陷病毒感染者血象变化特点[J].临床荟萃,2004,19(14):810-811. [6] 周挚,李淑娈,黎承萍,等.HIV感染的临床血液学特点[J].西部医学,2007,19(5):815-816. [7] 梁季军.37例艾滋病患者的骨髓象及临床意义[J].广西医学,2007,29(12):1929-1930. [8] Moore DM, Awor A, Downing RS, et al. Determining eligibility for antiretroviral therapy in resource-limited settings using total lymphocyte counts, hemoglobin and boby mass index[J].AIDS Res Ther,2007,4:1. [9] Mwanburi DM, Ghosh M, Fauntleroy J, et al. Predicting CD4 count using total lymphocyte count: a sustainable tool for clinical decisions during HARRT use[J].Am J Trop Med Hyg,2005,73:58-62. [10] 张言敏,谷永斌,徐正厚,等.HIV慢性感染者总淋巴细胞计数与CD4+细胞计数间相关性研究[J].中国自然医学杂志,2008,3(10):161-164. [11] 叶景荣,孙伟东,张芹,等.北京市2006年HIV感染者CD4+T淋巴细胞计数与总淋巴细胞计数间相关性研究[J].中国自然医学杂志,2007,5(9):401-403. [12] Hollenbaugh JA,Munger J,Kim B.Metabolite profiles of human immunodeficiency virus infected CD4+ T cells and macrophages using LC- MS/MS analysis[J].Virology,2011,415(2):153- 159. [13] 靳昌忠,冯磊,吴南屏.HIV感染疾病进展的预测指标[J].中华传染病杂志,2010,28(10):636-640. [14] 林云霞,刘学真,郑薇,等. 山东省全球基金艾滋病项目地区抗病毒治疗病人CD4+T 细胞计数变化分析[J].中华疾病控制杂志,2009,13(4) : 484-485. [15] When To Start Consortium,Sterne JA,May M,et al. Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients:a collaborative analysis of 18 HIV cohort studies [J].Lancet,2009, 373(9672) : 1352-1363.