Abstract：To investigate the prenatal screening status of Down syndromes (DS), and to explore the influencing factors of prenatal screening with DS. Methods: Serum levels of alpha fetoprotein(AFP) and Free-β-human chorionic gonadotrop(h)in (Free- β HCG) of in 50420 cases of pregnant women with(14~20) gestational weeks were detected by using time-resolved immunofluorometric assay, and the results and pregnancy outcome were analyzed. 928 cases of delivery in hospital patients were divided into two groups ccording to whether or not to accept the DS prenatal screening. Different factors between groups were compared. Results: 10.13% (5106 cases) in 50420 cases of pregnant women had high risk. 2625 cases (51.41%) were analyzed karyotypes of amniotic fluid cell, and 28 cases had abnormal fetal karyotype (1.07%). 601 patients received DNA noninvasive detection and were confirmed 3 cases of 21- syndrome, and 1780 cases that had delivery but notaccepted amnioticfluid cells karyotype analysts accepted follow-up and confirmed that 12 cases of 18- syndrome and 5 cases of trisomy 21-syndrome. Investigation shows that the availability of DS prenatal screening was lower in pregnant women with low cultural level, non local household registration and unknown the DS prenatal screening. Conclusion: The DS prenatal has great significance for reducing the birth rate of DS. To strengthen the education of DS prenatal screening and antenatal care for foreign pregnant woman can increase the use of DS prenatal screening service.
潘素招, 宋春仙, 李玲珠. 台州市50420例唐氏综合症产前筛查情况及影响服务利用的因素分析[J]. 实用预防医学, 2015, 22(1): 92-93.
Pan Su-zhao, Song Chun-xian, Li Ling-zhu.. Prenatal screening status of Down syndromes in 50420 cases on middle period pregnancy and influence factors of this service. , 2015, 22(1): 92-93.
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2015, Vol. 22 
