Epidemiological survey on two human infection cases with avian influenza A(H7N9) virus in Yueyang City and analysis of the environment monitoring results
DAI Meng*, CAI Ya-hui, HUANG Yi-wei, LOU Chang-xing, CHEN Dong, YUAN Dan, LIANG Yan, ZHANG Hong
*Yueyang Municipal Center for Disease Control and Prevention, Yueyang, Hunan414000, China
摘要 目的对2014年岳阳市2例人感染H7N9禽流感确诊病例的流行病学特征、外环境病原学监测结果进行分析，为人感染H7N9禽流感的防控提供依据。方法采用流行病学个案调查与描述性流行病学相结合方法，收集与分析2例确诊病例的流行病学相关资料;采集病人咽拭子2份、密切接触者咽拭子6份、针对病人周边外环境样本118份、扩大监测外环境样本283份。采用Real time RT-PCR检测样本中的H7N9禽流感病毒核酸。结果2例患者均为城镇女性，年龄60岁左右，有基础病史，病人发病前均有禽类接触史或污染的外环境暴露史，发病后经多家医院转诊治疗无效均死亡。病人咽拭子均为阳性、密切接触者咽拭子均为阴性，针对病人周边外环境样本阳性率为12.7%，扩大监测外环境样本阳性率为4.95%。结论外环境中的禽流感病毒可能是病例的传染来源。应定期开展岳阳市禽类市场及相关场所外环境H7N9禽流感病毒污染状况监测。
Abstract：Objective To analyze the epidemiological data and environment monitoring results of two confirmed human infection cases with avian influenza A(H7N9) virus in Yueyang City, so as to provide scientific basis for the prevention and control of H7N9 infection. MethodsThe epidemiological data of two human infection cases with avian influenza A(H7N9) virus in Yueyang City were collected and analyzed by epidemiological case study combined with descriptive epidemiology. Two samples of throat swab from the patients, 6 samples of throat swab from the close contacts, 118 samples from the surrounding environment of the patients and 283 samples from the expanded monitoring environment were collected. Real time RT-PCR was used to detect the nucleic acid of the avian influenza (H7N9) virus in the samples. ResultsThe two patients were both urban women aged about 60 years old with disease history. Both patients had contacted with poultry or been exposed to contaminated surroundings before getting infected, and both died after rounds of invalid treatment in several hospitals. The 2 samples from the patients were found to be H7N9 positive. The 6 samples from the close contacts were found to be H7N9 negative. The H7N9 positive rate of samples from the surrounding environment of the patients was 12.7% and that of the samples from the expanded monitoring environment was 4.95%. ConclusionsAvian influenza virus from the external environment might be the infectious resource of the two human infection cases with avian influenza A (H7N9) virus in Yueyang City. Periodical monitoring on the contamination by H7N9 virus in the poultry market and external environment of related sites should be strengthened.
戴猛, 蔡亚辉, 黄一伟, 娄常兴, 陈东, 袁丹, 梁艳, 张红. 岳阳市2例人感染H7N9禽流感病例流行病学调查与外环境监测结果分析[J]. 实用预防医学, 2015, 22(1): 52-55.
DAI Meng*, CAI Ya-hui, HUANG Yi-wei, LOU Chang-xing, CHEN Dong, YUAN Dan, LIANG Yan, ZHANG Hong. Epidemiological survey on two human infection cases with avian influenza A(H7N9) virus in Yueyang City and analysis of the environment monitoring results. , 2015, 22(1): 52-55.
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2015, Vol. 22 
