Abstract：ObjectiveTo investigate the protective effect of trimetazidineon on myocardial damage in diabetic rats.MethodsSixty healthy male SD rats were randomly divided into control group, diabetes group, experimental group A, B and C, with 12 rats in each group. The rats in the control group were fed with standard granule feed, while those in the other groups were fed with high-sugar, high-fat feed, Six weeks later, the rats in the diabetes group, experimental group A, B and C were intraperitoneally injected with 30mg/kg streptozotocin (STZ), and 72 hours thereafter, their blood glucose (BG) was determined twice and those with both BG above 11.1mmol/L were continually kept with high-sugar, high-fat feed for 6 weeks. Besides, the rats in the experimental group A, B and C were respectively intraperitoneally injected with 10, 30 and 90mg/kg/d trimetazidine. Serum CK, LDH, TGF-β1, TNF-ɑ and ATP, ADP, AMP and MDA contents as well as SOD activity in the myocardial tissue were detected.ResultsDuring the experiment, the body weight gain of the diabetic rats were significantly lower than those of the control group and the experimental groups (P<0.05), and the differences between those of the experimental groups and that of the control group were not statistically significant (P>0.05). Compared with the control group, the serum CK, LDH, TGF-β1,TNF-ɑ levels and the myocardial MDA and ADP contents in the diabetes group were significantly increased （P<0.05）, while the myocardial ATP,AMP contents and SOD activity were significantly decreased（P<0.05）. Compared with the diabetes group, the serum CK, LDH and myocardial ADP contents in the three exprimental groups, and the serum TGF-β1,TNF-ɑ and myocardial MDA contents in experimental group B and C were significantly lower（P<0.05）, while the myocardial AMP levels in the three experimental groups as well as SOD activity and ATP contents in the experimental group B and C were significantly higher（P<0.05）.ConclusionsTrimetazidineon has obvious protective effect on myocardial damage in diabetic rats.
2015, Vol. 22 
