Abstract:Objective To analyze the status and death causes of pregnancy complicated with maternal heart disease so as to provide a basis for putting forward targeted intervention measures to reduce the maternal mortality. Methods The data of 22 maternal deaths due to pregnancy combined with heart disease in Zhengzhou City from 2006 to 2015 were analyzed retrospectively. Results The deaths from heart diseases in pregnant women accounting for 11.11% of the total maternal deaths. The mortality from heart diseases in pregnant women in Zhengzhou City during 2006-2015 was 2.10 /100,000, and it decreased from 2.47/100,000 in 2006-2010 to 1.78/100,000 in 2011-2015. For the 22 maternal deaths, the top 3 heart diseases were congenital heart defects (45.45%), peripartum cardiomyopathy (18.18%) and rheumatic heart disease (13.64%). The mortality was higher in rural areas than in city (2.75/100,000 vs. 1.02/100,000, χ2=3.893, P=0.048). The deaths with educational background of junior middle school or below, with the family annual income per capita less than RMB 4,000 yuan, with prenatal examination less than 5 times as well as with regular medication and regular follow-up accounted for 72.73%, 59.09%, 77.27% and 9.09% respectively. The avoidable deaths were mainly attributed to knowledge, skills and attitude of individuals and family(87.50%)and knowledge, skills and management of county-level medical institutions(12.50%). Conclusions Pregnancy complicated with heart disease is one of the main causes of maternal deaths in Zhengzhou City during 2006-2015. It is necessary to enhance health education and systematic management of maternal health, improve healthcare awareness of the maternal and skills of medical professionals and strengthen multi-disciplinary collaboration so as to control the occurrence of maternal death in pregnant women with heart disease.