Abstract:Objective To investigate the new infection status of newly reported HIV infectors/AIDS patients in Hubei Province. Methods We collected the information of new reported HIV/AIDS cases in Hubei Province from 2010 to 2014 and screened the samples of HIV infectors with the firstly confirmed diagnosis of HIV-1 antibody positivefor BED assay to identify new infection. The proportions of new HIV/AIDS infections among different populations were calculated, and a stratified analysis method was used to analyze the factors affecting the new HIV/AIDS infections with respect to demographic characteristics, transmission routes and sample sources. Results The proportions of the new HIV/AIDS infections with homosexual, heterosexual as well asinjection drug abuse andother transmission routes were 31.47%, 15.76% and 14.10% respectively, showing statistically significant differences (P<0.001). Compared with the patients aged > 50 years, the ones aged ≤ 30 years were more likely to be new infectors (OR=1.284, 95%CI1.065-1.549,P=0.009). Compared with farmers and migrant workers, the commercial service clerks, young students and cadre staff were more likely to be new infectors (OR=1.412-2.616,P=0.034~<0.001). Compared with the patients identified by hospitals, the new HIV/AIDS infections were more likely to be found through voluntary counseling and testing, MSM intervention, project-based surveillance, HIV positive spouses, sexual partners, custody personnel, voluntaryblood donators and STD clinics (OR=1.559-2.576,P=0.004~<0.001). Conclusions The new infection proportion in the newly reported HIV infectors/AIDS patients in Hubei Province in 2010-2014is the highest among MSM . Medical institutions and non-governmental organizations should pay a bigger role in promoting HIV testing in high-risk groups and reduce the secondary transmission.