Latent tuberculosis infection among freshmen in a college in Changping District, Beijing
DU Feng-jiao*, ZHANG Zhi-guo*, GAO Tie-jie, LIU Zhong-quan, CHEN Xi, CAO Ting-ming, JIA Hong-yan, XING Ai-ying, DU Bo-ping, ZHANG Zong-de
Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University,Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
Abstract：Objective To investigate the prevalence of latent tuberculosis infection (LTBI) among freshmen so as to take preventive interventions. Methods Four hundred and twenty newly-admitted college students with positive results of tuberculin skin test (TST, diameter ≥ 10mm) were randomly enrolled from a college in Changping District, Beijing in October 2010. Enzyme-linked immunospot assay (ELISPOT) was used to detect the peripheral blood T lymphocytes that secreted IFN-γ after antigen stimulation, spot forming cells (SFCs), in all participants. Then the participants with positive results of ELISPOT were routinely monitored for 3 years to investigate the incidence of active tuberculosis (TB). Results The overall positive rate of LTBI by ELISPOT was 41.2%. No statistically significant difference was found in the positive rates of between the participants with and without BCG vaccination (41.5% vs. 40.0%, χ2=0.064, P=0.447), but there were statistically significant differences in the positive rates among the groups with TST induration of 10-14 mm, 15-19 mm and ≥ 20 mm (37.6%, 45.4% and 64.3% respectively, χ2=8.408, P=0.015). The 173 untreated students with ELISPOT+/TST+ were followed up for 3 years, and none was found to develop active TB. Conclusions The prevalence of latent tuberculosis infection among the freshmen of the college in Changping District, Beijing is high. Only taking ELISPOT+/TST+ as the indicators for tuberculosis prophylaxis treatment is not enough.
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2016, Vol. 23 
