Abstract:Objective To investigate the prevalence of colorectal cancer (CRC) in Fogang District and to explore its influencing factors. Methods Forty-eight villages or communities in Fogang District were randomly selected as the survey points. The high-risk population was identified by a unified questionnaire survey, and then received the fecal occult blood test as a preliminary screening, and those with positive Results were further re-screened by colonoscopy for confirmatory diagnosis. Factors affecting the incidence of CRC were analyzed by logistic regression analysis. Results Totally, 47,400 residents were recruited, and 34,286 effective questionnaires were retrieved, with the compliance rate of 72.33%. 26,572 participants accepted the preliminary screening and 1,662 got positive Results, with the positive rate of 6.25%. 980 participants accepted the colonoscopy and 35 (3.57%) were found to have colorectal cancer. High nitrite diet(OR=2.073), high fat diet (OR=2.462)and gallbladder stones(OR=2.659) were the risk factors for CRC, and high dietary fiber(OR=0.637) was the protective factor. Conclusions Colorectal cancer screening can effectively identify patients with colorectal cancer among the asymptomatic populations, which is conducive to early treatment and prognosis of the colorectal cancer patients . CRC screening compliance in residents in Fogang District is relatively low, and related health education should be strengthened.