Abstract：Objective To analyze the influence of fasting plasma glucose (FPG) in early pregnancy on gestational diabetes mellitus (GDM). Methods From October 7, 2014 to April 30, 2015, 975 pregnant women who took the first trimester examination within 13 weeks of pregnancy in Yushan Town Community Health Service Center or Zhangpu Community Health Service CenterIn Kunshan City were recruited by cluster random sampling. Maternal information like age and education was collected. Height, weight, systolic blood pressure (SBP), diastolic blood pressure (DBP), FPG and hemoglobin A1c and hemoglobin (HB) were detected in the first trimester examination. They were followed up for 24-28 weeks and oral glucose tolerance test (OGTT) was conducted. The influence of FPG in early pregnancy on GDM was analyzed by univariate and multivariate analysis. Results The incidence of GDM in this region was 21.85%. The paritcipants were divided into four groups based on the FPG quartiles (4.40 mmol/L, 4.75 mmol/L, 5.05 mmol/L) in early pregnancy. The incidence of GDM increased with the rise of FPG in early pregnancy (χ2trend =48.96,P<0.01). When multiple factors including maternal age, body mass index, SBP, DBP, HB and FPG detected in the first trimester examination were adjusted, having the lowest quantile of FPG (≤4.40 mmol/L)as the control, the third (>4.75~5.05) and the forth quartile (>5.05) could both increase the risk of GDM, with the adjusted ORs(95%CI) of 2.87(1.74-4.74) and 4.18(2.56-6.82), respectively. Moreover, there presented a dose-response relationship between fasting glucose in early pregnancy and gestational diabetes mellitus(χ2trend=48.96,P<0.01). Conclusion High fasting plasma glucose in early pregnancy can increase the risk of gestational diabetes mellitus in a dose-response manner.
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2016, Vol. 23 
