Abstract：Objective To make a matched-pair study on the dynamic changes of measles antibody level in mothers and their neonates, to explore the causes of the high incidence rate of measles in newborn infants so as to provide theoretical evidence for formulating measles immunization strategy. Methods A cross-sectional study was made. 2 ml maternal peripheral blood and 2 ml umbilical cord blood (UCB) during parturition, which informed a neonate’s initial antibody level at birth, were collected in 58 pairs of mothers and their neonates. A follow-up study was conducted among the neonates at the 3rd, 5th and 7th months after birth. The serum IgG antibody levels of the mothers and neonates were determined by ELESA with reagents from German LBL Company. Results The measles antibody titers in sera of mothers during pregnancy (maximum 6,522, minimum 62, median 834.5) and in UCB of neonates (maximum 6,233, minimum 61, median 760.5) were not significantly different (t=0.87, P=0.39). The serum antibody positive rates and antibody protective rates in the mothers and UCB of the neonates were 84.48% and 86.21%, 50.00% and 46.55% respectively. There was a positive correlation between the maternal measles antibody level and the neonates’ (r=0.83, P<0.01). The antibody levels in the UCB of the neonates were elevated with the increase of their mothers’ antibody levels (χ2=42.85, P<0.01). The positive rates of serum antibody in the neonates at the 3rd and 5th months were 29.27% and 5.88% respectively, but the serum antibody turned to be negative in all neonates at the 7th months and thereafter. The positive rate of protective antibody in the UCB of the neonates with positive- antibody mothers was higher than that of those with negative-antibody mothers (89.66% vs. 3.45%, χ2=20.06, P<0.01). The positive rate of measles protective antibody in the neonates at the 3rd month and thereafter decreased to 0 despite their mothers with or without the protective antibody. Conclusions The measles antibody level in the neonates is low and falls rapidly. Maternal-transferred measles antibody turns to be negative in the neonates at the 7th month; moreover, it is not protective since the 3rd month. The measles antibody levels of the neonates are directly influenced by those of women of childbearing age. Pre-pregnancy vaccination can improve the neonates’ measles antibody in a certain degree.
唐广心, 连昌虎, 刘晓军. 58对母婴麻疹抗体水平衰减的研究[J]. 实用预防医学, 2016, 23(10): 1190-1192.
TANG Guang-xin, LIAN Chang-hu, LIU Xiao-jun. Attenuation of measles antibody in 58 pairs of mothers and neonates. , 2016, 23(10): 1190-1192.
2016, Vol. 23 
