Establishment of normal reference ranges of 42 mineral elements in adult blood and the differences in ages and genders in Hunan Province
YI Haiyan1, NIE Yunfeng1, FU Sheng1, ZHOU Lezhou1, YANG Lu1, LI Qi1, XIE Yanhong2, DU Han3
1. Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan 410007, China; 2. Chenzhou Municipal Center for Disease Control and Prevention, Chenzhou, Hunan 423000, China; 3. Xiangxi Autonomous Prefecture Center for Disease Control and Prevention, Jishou, Hunan 416000, China
Abstract：Objective To investigate the normal reference ranges of 42 mineral elements like beryllium(Be), magnesium(Mg), calcium(Ca), vanadium(V), chromium(Cr), ferrum (Fe), manganum(Mn), cobaltum(Co), nickel(Ni), copper(Cu), zinc(Zn), gallium(Ga), arsenic(As), selenium(Se), rubidium(Rb), strontium(Sr), yttrium(Y), molybdanium(Mo), cadmium(Cd), stannum(Sn), stibium(Sb), tellurium(Te), caesium(Cs), lanthanum(La), praseodymium(Pr), neodymium(Nd), samarium(Sm), europium(Eu), gadolinium(Gd), terbium(Tb), dysprosium(Dy), holmium(Ho), erbium(Er), thulium(Tm), ytterbium(Yb), lrtetium(Lu), wolfram(W), thallium(Tl), lead (Pb), uranium(U) and mercury(Hg) in whole blood of adults in Hunan Province, and to analyze their distribution in the population. Methods Anticoagulated venous blood samples were randomly collected from 1,553 adults from 14 prefecture-level cities in Hunan Province from 2019 to 2020. Inductively coupled plasma-mass spectrometry (ICP-MS) and atomic fluorescence spectrometry (AFS) were used to determine the 42 mineral elements like Be in the blood samples. The normal reference ranges of the above-mentioned mineral elements in Hunan Province were established, and the contents and distribution of the mineral elements among adults with different ages and genders were analyzed. Results The normal reference ranges of the above-mentioned 42 mineral elements in blood of the adults in Hunan Province were established, of which statistically significant differences were found in the contents of Mg, Ca, V, Fe, Mn, Co, Ni, Cu, Zn, Ge, As, Se, Rb, Sr, Y, Mo, Cd, Sn, Sb, Te, La, Nd, Gd, Tl and Hg between males and females (P<0.05) as well as in the contents of Ca, V, Cr, Fe, Co, Ni, Zn, Ga, Ge, As, Se, Rb, Y, Mo, Cd, Sb, Te, Cs, La, Sm, Gd, Tl and Pb among adults of different age groups (P<0.05). Conclusion The normal reference ranges of the 42 mineral elements in blood of the adults in Hunan Province are established, which provide a good basis and references for setting up regional element distribution database and clinical diagnosis application.
易海艳, 聂云峰, 傅胜, 周乐舟, 杨露, 李祈, 谢艳红, 杜菡. 湖南省成人血液中42种矿物质元素参考值范围确立及年龄性别差异分析[J]. 实用预防医学, 2023, 30(12): 1439-1444.
YI Haiyan, NIE Yunfeng, FU Sheng, ZHOU Lezhou, YANG Lu, LI Qi, XIE Yanhong, DU Han. Establishment of normal reference ranges of 42 mineral elements in adult blood and the differences in ages and genders in Hunan Province. , 2023, 30(12): 1439-1444.
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2023, Vol. 30 
