Abstract：Objective To evaluate the vaccination status, safety and protective effect of influenza vaccines among children in Lucheng District of Wenzhou City from 2020 to 2021. Methods Outpatient children from Pediatric Healthcare Department of Wenzhou People's Hospital from September to December 2020 served as the survey subjects. The vaccination status of 7,053 surveyed children aged 6 months to 14 years was statistically analyzed, and then 500 vaccinated children were selected as the observation group. At the same time, 500 un-vaccinated children were selected as the control group. The adverse reactions and protective effect of the vaccines were observed. Results The vaccination rate of the surveyed children was 7.60% (536/7,053), among which 54.1% (290/536) were fully vaccinated. Among the 500 children of the observation group whoreceived influenza vaccines, the incidence rate of adverse reactions was 3.4%, mainly including fever, pain and redness or swelling at the injection site. After 1 year of follow-up, the difference in the disease risk between the observation group and the control group was 0.43 times, and the protective effect of the vaccines was 62.8% (95%CI:46.2%-74.2%). The protective effects of partial vaccination and complete vaccination in the group aged 6-35 months were 22.2% (95%CI:0%-73.9%) and 59.4% (95%CI:6.3%-82.4%), respectively. The protective effects of partial vaccination and complete vaccination in the group aged 36-59 months were 48.7% (95%CI:5.2%-72.2%) and 79.2% (95%CI:29.9%-93.8%), respectively. The protective effects of partial vaccination and complete vaccination in the group aged 5-14 years were 61.1% (95%CI:4.1%-84.2%) and 79.8% (95%CI:53.7%-91.1%), respectively. Conclusion The influenza vaccination rate in the surveyed children in Lucheng District of Wenzhou City from 2020 to 2021 was relatively low, with less complete vaccination. Vaccination is conducive to reducing the incidence rate of influenza, and the protection effect of completing the whole course of immunization is better.
杨映, 张宇, 陈红, 林克武. 2020—2021年度温州市鹿城区儿童流感疫苗应用现状及安全性和保护效果研究[J]. 实用预防医学, 2023, 30(3): 296-299.
YANG Ying, ZHANG Yu, CHEN Hong, LIN Ke-wu. Application status, safety and protective effect of influenza vaccines among children in Lucheng District of Wenzhou City, 2020-2021. , 2023, 30(3): 296-299.
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