Abstract：Objective To explore the necessity of mercury displacement test in living mercury-exposed people with urine mercury ranged from 4 μg/gCr to 35 μg/gCr. Methods A retrospective study was conducted on living mercury-exposed subjects with urine mercury ranged from 4 μg/gCr to 35 μg/gCr from the Outpatient Department of Nanjing Prevention and Treatment Center for Occupational Diseases from June 2016 to April 2021. According to whether the subjects underwent mercury displacement test, they were divided into the displacement group (n=24) and the control group (n=52). The subjects in the displacement group underwent mercury displacement test with sodium 2,3-dimercaptopropane sulfonate (DMPS), while the subjects in the control group were treated with natural mercury removal. Urine mercury at baseline, symptoms and signsand follow-ups after one month, three and six months were compared between the two groups. Results Before the mercury displacement test, there were no statistically significant differences in patients’ ages, baseline urinary mercury, symptoms and signs between the displacement group and the control group (all P>0.05). After one month, three and six months of follow-up, urine mercury in the displacement group decreased to (4.69±1.63)μg/gCr, (3.18±0.84)μg/gCr and (1.90±0.72)μg/gCr, respectively, while urine mercury in the control group decreased to (12.60±4.29)μg/gCr, (6.79±2.62)μg/gCr, and (3.63±1.31)μg/gCr, respectively, showing statistically significant differences (all P<0.001). After one month and three months of follow-up, the improvement rates of neurasthenic syndrome, edema and positive urine microalbumin in the displacement group were significantly higher than those in the control group, and the differences were statistically significant (all P<0.05). After six months of follow-up, no statistically significant differences were found in the improvement of neurasthenic syndrome, oral-gingivitis, tremor, edema, positive urine protein and positive urine microalbumin between the displacement group and the control group (all P>0.05). Conclusion Mercury displacement test is necessary for early diagnosis and treatment of living mercury-exposed people with urine mercury ranged from 4 μg/gCr to 35 μg/gCr.
吉卉霞, 涂雷, 陈晔, 刘丹丹. 生活性汞接触者行驱汞试验的必要性研究[J]. 实用预防医学, 2023, 30(2): 186-189.
JI Hui-xia, TU Lei, CHEN Ye, LIU Dan-dan. Necessity of mercury displacement test in living mercury-exposed people. , 2023, 30(2): 186-189.
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