Abstract：Objective To investigate the internal exposure levels ofphthalic acid esters (PAEs)and their influencing factors amongst adult residents in Guangzhou City. Methods Three hundred and ten permanent residents aged ≥18 years were selected for a questionnairesurvey in Guangzhou City in 2020, and their urine samples were collected. High-performance liquidchromatography-electrospray ionization-tandem mass spectrometry method was used to determine the concentration of 7 phthalate monoesters in each urine sample, including monomethyl phthalate (mMP), monoethyl phthalate (mEP), monobutyl phthalate (mBP), monoisobutyl phthalate (miBP), mono (2-ethyl-5-oxohexyl) phthalate (mEOHP), mono (2-ethyl-5-hydroxohexyl) phthalate (mEHHP), and mono-ethylhexyl phthalate (mEHP). Univariate analysis and multivariate logistic regression analysis were used to identify the factors affecting the phthalate monoester levels among the residents. Results The medians of mMP, mEP, mBP, miBP, mEOHP, mEHHP and mEHP concentration in the 310 urine samples were 6.148 ng/ml, 9.956 ng/ml, 240.121 ng/ml, 37.632 ng/ml, 12.386 ng/ml, 16.985 ng/ml and 13.674 ng/ml, respectively. And the daily exposure was 0.346 ng/(g·d), 0.603 ng/(g·d), 15.689 ng/(g·d), 2.459 ng/(g·d), 5.493 ng/(g·d), 5.486 ng/(g·d) and 11.301 ng/(g·d), respectively. The daily exposure of mBP was higher than the allowable reference exposure, and it was the most important PAEs exposure among residents in Guangzhou. The results of multivariate logistic regression analysis indicated that the urinary concentration of mBP showed a decreasing trend with the improvement of education level, the OR (95%CI) of high school/vocational high school education was 0.454 (0.219-0.940), and the OR (95%CI) of junior college or above was 0.449 (0.216-0.934). Participants who had their hair permed and dyed had higher urinary level of mBP, the OR (95%CI) annually was 1.770 (1.051-3.233), and the OR (95%CI) biannual was 2.113 (1.156-3.865). Participants who ate aquatic products in 24 hours had higher urinary level of mBP, and the OR (95%CI) was 2.751 (1.018-4.048). Participants who ate fried food more than twice a week had higher urinary level of mBP, and the OR (95%CI) was 1.255 (1.007-2.882). Conclusion Adult residents in Guangzhou are generally exposed to phthalate, and mBP exposure per day is a health risk. The internal exposure level of mBP is associated with most measured factors.
宋韶芳, 周金华, 李琴, 黎晓彤, 石同幸. 广州市成年居民邻苯二甲酸酯内暴露水平及影响因素研究[J]. 实用预防医学, 2023, 30(2): 156-160.
SONG Shao-fang, ZHOU Jin-hua, LI Qin, LI Xiao-dong, SHI Tong-xing. Internal exposure levels of phthalic acid esters and their influencing factors among adult residents in Guangzhou City. , 2023, 30(2): 156-160.
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2023, Vol. 30 
