Abstract：Objective To explore the association between alcohol intake and the risk of chronic obstructive pulmonary disease (COPD). Methods PubMed, Web of Science, Embase, CNKI, Wanfang database, and Weipu database were searched online to collect observational studies on alcohol intake and the risk of COPD published from the establishment of each database through November 2021. Two researchers independently screened the literature according to the inclusion and exclusion criteria and then extracted the data. Statistical analyses were performed using Stata 12.0 software. Results A total of 8 articles (2 cohort and 6cross-sectional studies) were included, and 209,489 participants were pooled into this meta-analysis. Results of this meta-analysis showed that there was no significant change in COPD risk in the group with the highest alcohol intake (RR=0.97, 95%CI:0.87-1.08) compared with that in the group with the lowest alcohol intake. The group with light or moderate alcohol intake had a lower risk of COPD (RR=0.87, 95%CI:0.81-0.94) compared with the group without drinking. No significant change was found in COPD risk in the group with excessive alcohol intake (RR=1.26, 95%CI:0.98-1.63) compared with the group with light or moderate alcohol intake. Conclusion Results of this meta-analysis suggest that light or moderate alcohol intake may reduce the risk of COPD. And further studies are needed to analyze whether excessive alcohol intake can increase the risk of COPD.
阮春燕, 林俏丽, 蔡倩, 邬欣桃, 刘婵娟, 耿金花. 饮酒与慢性阻塞性肺疾病风险关系的meta分析[J]. 实用预防医学, 2022, 29(11): 1328-1332.
RUAN Chun-yan, LIN Qiao-li, CAI Qian, WU Xin-tao, LIU Chan-juan, GENG Jin-hua. Meta-analysis on the relationship between alcohol intake and the risk of chronic obstructive pulmonary disease. , 2022, 29(11): 1328-1332.
[1] 刘俊, 骆玉兔, 田胤纯, 等. 血清炎性因子水平与慢性阻塞性肺疾病患者严重程度相关性研究[J]. 实用预防医学, 2021, 28(10):1248-1251. [2] Xie M, Liu X, Cao X, et al. Trends in prevalence and incidence of chronic respiratory diseases from 1990 to 2017[J]. Respir Res, 2020, 21(1):49. [3] Lozano R,Naghavi M,Foreman K,et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010[J]. Lancet, 2012, 380(9859):2095-2128. [4] 潘东霞,钱一建,王春梅,等. 吸烟与室内空气污染的交互作用对慢性阻塞性肺部疾病影响的分析[J]. 中华流行病学杂志, 2016, 37(11):1444-1449. [5] Eisner MD,Balmes J,Katz PP,et al. Lifetime environmental tobacco smoke exposure and the risk of chronic obstructive pulmonary disease[J]. Environ Health, 2005, 4(1):7. [6] Lu C, Liao B, Nie J, et al. The association between sleep duration and chronic diseases: a population-based cross-sectional study[J]. Sleep Med, 2020, 73:217-222. [7] 雷雅麟,辛军国,杨春松,等. 久坐行为与成年人多种慢性疾病的关联研究[J]. 现代预防医学, 2020, 47(17):3158-3163. [8] Salari-Moghaddam A, Milajerdi A, Larijani B, et al. Processed red meat intake and risk of COPD: a systematic review and dose-response meta-analysis of prospective cohort studies[J]. Clin Nutr, 2019, 38(3):1109-1116. [9] Kaluza J,Larsson SC,Orsini N,et al. Fruit and vegetable consumption and risk of COPD: a prospective cohort study of men[J]. Thorax, 2017, 72(6):500-509. [10] Varraso R, Chiuve SE, Fung TT, et al. Alternate Healthy Eating Index 2010 and risk of chronic obstructive pulmonary disease among US women and men: prospective study[J]. BMJ, 2015, 350:h286. [11] Meteran H, Thomsen SF, Miller MR, et al. Self-reported intake of fruit and vegetables and risk of chronic obstructive pulmonary disease: a nation-wide twin study[J]. Respir Med, 2018, 144:16-21. [12] Ng R, Sutradhar R, Yao Z, et al. Smoking, drinking, diet and physical activity-modifiable lifestyle risk factors and theirassociations with age to first chronic disease[J]. Int J Epidemiol, 2020, 49(1):113-130. [13] Tabak C,Smit HA,Räsänen L,et al. Alcohol consumption in relation to 20-year COPD mortality and pulmonary function in middle-aged men from three European countries[J]. Epidemiology, 2001, 12(2):239-245. [14] Kaluza J, Harris HR, Linden A, et al. Alcohol consumption and risk of chronic obstructive pulmonary disease: a prospective cohort study of men[J]. Am J Epidemiol, 2019, 188(5):907-916. [15] Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses[J]. Eur J Epidemiol, 2010, 25(9):603-605. [16] Herzog R,álvarez-Pasquin MJ,Díaz C,et al. Are healthcare workers' intentions to vaccinate related to their knowledge, beliefs and attitudes? A systematic review[J]. BMC Public Health, 2013, 13:154. [17] Zhang J, Yu KF. What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes[J]. JAMA, 1998, 280(19):1690-1691. [18] 周权,郭鹏,钟国超,等. 有序多分类剂量反应资料meta分析中原始研究参照组转换及软件实现[J]. 循证医学, 2016, 16(1):60-64. [19] 江虹. 衢江区农村吸烟人群慢性阻塞性肺疾病影响因素调查[J]. 中华全科医学, 2013, 11(6):923-929. [20] 杨荣荣. 藏族人群COPD患病率和危险因素及藏-汉人群的对比研究[D]. 广州:广州医科大学, 2013. [21] Oh CM, Oh IH, Choe BK, et al. Consuming green tea at least twice each day is associated with reduced odds of chronic obstructive lung disease in middle-aged and older Korean adults[J]. J Nutr, 2018, 148(1):70-76. [22] Zhao C, Wong L, Zhu Q, et al. Prevalence and correlates of chronic diseases in an elderly population: a community-based survey in Haikou[J]. PLoS One, 2018, 13(6):e199006. [23] Song P,Zha M,Xia W,et al. Asthma-chronic obstructive pulmonary disease overlap in China: prevalence, associated factors and comorbidities in middle-aged and older adults[J]. Curr Med Res Opin, 2020, 36(4):667-675. [24] Shen C, Ni MY, Schooling CM, et al. Alcohol use and death from respiratory disease in a prospective Chinese elderly cohort study in Hong Kong[J]. Prev Med, 2013, 57(6):819-823. [25] Sisson J H. Alcohol and airways function in health and disease[J]. Alcohol, 2007, 41(5):293-307. [26] Estruch R, Sacanella E, Mota F, et al. Moderate consumption of red wine, but not gin, decreases erythrocyte superoxide dismutase activity: a randomised cross-over trial[J]. Nutr Metab Cardiovasc Dis, 2011, 21(1):46-53. [27] Beulens JW, de Zoete EC, Kok FJ, et al. Effect of moderate alcohol consumption on adipokines and insulin sensitivity in lean and overweight men: a diet intervention study[J]. Eur J Clin Nutr, 2008, 62(9):1098-1105. [28] Estruch R, Sacanella E, Badia E, et al. Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of wine on inflammatory markers[J]. Atherosclerosis, 2004, 175(1):117-123. [29] Joshi PC,Guidot DM. The alcoholic lung: epidemiology, pathophysiology, and potential therapies[J]. Am J Physiol Lung Cell Mol Physiol, 2007, 292(4):L813-L823.
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