摘要目的 了解台州市男男性行为(men who have sex with men,MSM)人群中HIV-梅毒、HIV-HSV-2和梅毒-HSV-2共感染的发生情况。 方法 2019年1—12月在台州市招募居住MSM人群837名。收集参与者年龄、婚姻状况、民族、户籍地、学历、月收入、就业情况及自我认同性取向等个人信息。采集参与者静脉血行HIV、HSV-2及梅毒检测,并综合血清检测结果及患者临床病史、症状、体征等判断患者HIV感染情况、HSV是否处于活动期及梅毒分期情况。 结果 837名MSM人群中HIV、HSV-2及梅毒感染率分别为6.33%(53/837)、5.38%(45/837)、17.68%(148/837)。HSV-2感染人群中以现症感染为主,约占57.78%(26/45)。梅毒感染人群以一期梅毒为主,约占48.65%(72/148)。合并≥2种感染者约占6.33%(53/837)。合并2种感染者占6.09%(51/837),其中以HIV-梅毒合并感染率最高约3.23%(27/837)。合并3种感染者占0.24%(2/837)。 结论 台州市男男性行为人群HIV、HSV-2及梅毒合并感染发生率较高,应引起足够重视并给予积极应对。
[1] 中国疾病预防控制中心. 全国艾滋病/性病/丙肝综合防治数据信息年报 [R]. 北京:中国疾病预防控制中心性病艾滋病预防控制中心,2017:1-25. [2] Meng X,Zou H,Beck J, et al. Trends in HIV prevalence among men who have sex with men in China 2003-09: a systematic review and meta-analysis[J]. Sex Health, 2013, 10(3):211-219. [3] 中国疾病预防控制中心传染病预防控制处. 2020年2月中国甲乙丙类传染病疫情动态概要 [J]. 疾病监测, 2020, 35(3):186-187. [4] Zhu Z,Yan H,Wu S, et al. Trends in HIV prevalence and risk behaviours among men who have sex with men from 2013 to 2017 in Nanjing, China: a consecutive cross-sectional survey [J]. BMJ Open, 2019, 9(1):e021955. [5] Newman DR,Rahman MM,Brantley A, et al. Rates of new human immunodeficiency virus (HIV) diagnoses after reported sexually transmitted infection in women in Louisiana, 2000-2015: implications for HIV prevention [J]. Clin Infect Dis, 2020, 70(6):1115-1120. [6] Li D,Yang X,Zhang Z, et al. Incidence of co-infections of HIV, herpes simplex virus type 2 and syphilis in a large cohort of men who have sex with men in Beijing, China[J]. PLoS One, 2016,11(1):e0147422. [7] Chow EP,Wilson DP,Zhang L. HIV and syphilis co-infection increasing among men who have sex with men in China: a systematic review and meta-analysis[J]. PLoS One, 2011, 6(8):e22768. [8] 吴健, 张佳玉, 王旭婷, 等. 2012—2019年上海市男男性行为哨点人群人类免疫缺陷病毒-1感染和行为情况及影响因素分析 [J]. 疾病监测, 2021,36(5):452-456. [9] 汪涛, 来学惠, 李雷, 等. 中山市男男性行为人群艾滋病/性传播疾病危险行为及感染率现况调查 [J]. 实用预防医学, 2010, 17(7):1261-1263. [10] 谭京广, 陈琳, 蔡文德, 等. 深圳市男男性行为人群艾滋病性病感染及相关危险行为研究 [J]. 实用预防医学, 2009, 16(5):1638-1640. [11] 韩莹, 孙洁, 任庆莹, 等. 济南市男男性行为者HIV TP HCV HBV HSV-2检测结果及HIV感染影响因素 [J]. 中国艾滋病性病, 2020, 26(6):603-606. [12] Bourne N,Perry CL,Banasik BN, et al. Increased frequency of virus shedding by herpes simplex virus 2-infected guinea pigs in the absence of CD4+ T lymphocytes[J]. J Virol, 2019, 93(4):e01721. [13] 卢春如. 深圳市龙岗区MSM人群HIV、TP、HSV-2病毒感染状况及影响因素分析 [J]. 中国医药科学, 2019, 9(10):172-175. [14] Munawwar A, Gupta S, Sharma SK, et al. Seroprevalence of HSV-1 and 2 in HIV-infected males with and without GUD: study from a tertiary care setting of India[J]. J Lab Physicians, 2018, 10(3):326-331. [15] Giacomelli A, Micheli V, Cattaneo D, et al. Multidrug-resistant HIV viral rebound during early syphilis: a case report[J]. BMC Infect Dis, 2020, 20(1):273. [16] 闻立芳, 黄晓媚, 蒙雨莎, 等. 2015—2019年深圳市罗湖区预防艾滋病、梅毒和乙肝母婴传播效果分析[J]. 实用预防医学, 2021, 28(1):83-85. [17] Ho EL,Maxwell CL,Dunaway SB,et al. Neurosyphilis increases human immunodeficiency virus (HIV)-associated central nervous system inflammation but does not explain cognitive impairment in HIV-infected individuals with syphilis[J]. Clin Infect Dis, 2017, 65(6):943-948. [18] Wang Z,Liu L,Shen YZ, et al. The clinical and laboratory features of neurosyphilis in HIV-infected patients: a retrospective study in 92 patients[J]. Medicine (Baltimore), 2018, 97(9):e0078. [19] Wang X,Wang Z,Jiang X, et al. A cross-sectional study of the relationship between sexual compulsivity and unprotected anal intercourse among men who have sex with men in Shanghai, China [J]. BMC Infect Dis, 2018, 18(1):465.
2021, Vol. 28 
